Results 151 to 160 of about 3,926,244 (335)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Evaluation of a hybrid hydrostatic bearing for cryogenic turbopump application [PDF]
A hybrid hydrostatic bearing was designed to operate in liquid hydrogen at speeds to 80,000 rpm and radial loads to 440 n (100 lbf). The bearing assembly consisted of a pair of 20-mm angular-contact ball bearings encased in a journal, which was in turn ...
Hannum, N. P. +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Materials Research and TechnologySi3N4 ceramic bearings have demonstrated significant potential in augmenting the performance of liquid rockets. However, the operational conditions, including reciprocating use, ultra-high-speeds, and high-load impacts, impose more stringent requirements
Fei Chen +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Assessment of the operating characteristics of the SSME LOX turbopump pump-end bearing [PDF]
A bearing/shaft model of the SSME LOX turbopump was developed using the SHABERTH bearing/shaft math modeling computer code. A previously developed bearing/shaft thermal model of the SSME LOX turbopump turbine and bearing was used in conjunction with ...
New, L. S., Tiller, B. K.
core +1 more source
Prevention of damage to delicate connectors during mounting of heavy engines for testing [PDF]
, 1971 Air-bearing-pad principle, combined with monitoring system of the air-bearing force, prevents damage between electrical and mechanical connectors joining a large engine system to the test stand during remote mating.
Hendrickson, R. J.
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Friction power loss in ball bearings: Correlation with bearing skidding and cage motion stability
FrictionThis study introduces a prediction method for bearing friction power loss, focusing on the interplay of bearing skidding and cage motion stability on the tribological properties of ball bearings.
Mingkai Wang +5 more
doaj +1 more source
Eccentric Taylor-Couette Flow with orbital motion of the inner cylinder [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011) +3 more
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