Results 161 to 170 of about 317,209 (268)

On the Friction Characteristics of the Bearing made by Alloyed Metal

open access: yesTransactions of the Japan Society of Mechanical Engineers, 1942
NISHIHARA, Toshio, SASAKI, Tokio
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Study on Bearing Capacity Characteristics of an Axial Permanent Magnetic Bearing

open access: yesJournal of Applied Sciences, 2013
Zhang Gang   +4 more
openaire   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Measurement and Analysis on Bearing Characteristics of Gas Bearing Circulator,B1

open access: yesMeasurement and Analysis on Bearing Characteristics of Gas Bearing Circulator,B1
ヘリウムル-プ「HENDEL」に使用中のガスベアリング型循環機のベアリング荷重に関する測定及び解析を行った。これらの試験結果からジャ-ナルベアリングのパッドに作用する静荷重は予想されていたような一定値に留まらない上、作動気体の運動量及び圧力勾配と駆動用電動機における電磁力のよる外力に起因して、非等方的である事が明らかになった。ベアリングに作用する動荷重については、その値が静荷重に依存し、そのベクトルの絶対値は一回転中に変動する事も分かった。循環機シャフトの発散的振動は上記の動荷重の振動とスプリングピヴォットの比較的低い剛性に起因することが実験結果及び解析結果から推論され、予知された。ガスベアリング式循環機に関するこれらの弱点を解決するため、2・3の設計概念とこれらを具体化する方法についても言及した。
openaire  

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright   +10 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs   +7 more
wiley   +1 more source

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