Results 91 to 100 of about 6,390,732 (328)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Failure analysis of superconducting bearings
Journal of Physics: Conference Series, 2006 The dynamics of superconductor bearings in a cryogenic failure scenario have been analyzed. As the superconductor warms up, the rotor goes through multiple resonance frequencies, begins to slow down and finally touches down when the superconductor goes through its transition temperature.
Amit Rastogi, A M Campbell, T A Coombs
openaire +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Life Analysis of Wear Fatigue Competition Failure Mechanism of Main Bearing of Boring Machine
Shanghai Jiaotong Daxue xuebaoThe main bearing of a tunneling machine is prone to premature failure under the influence of multiple factors such as wear and fatigue during service, making it difficult to predict its lifetime.
NA Pengyue, WU Zhen, LIU Qi, HUO Junzhou
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Freight train-track-bridge dynamics under lateral connection failure
Results in EngineeringThis study investigates the effect of the failure of the lateral connection between the bearing and the beam on the dynamic characteristics of the freight train–track–bridge system.
Yuexing Wu +4 more
doaj +1 more source
Condition Monitoring of Horizontal Sieving Screens-A Case Study of Inertial Vibrator Bearing Failure in Calcium Carbonate Production Plant. [PDF]
Materials (Basel), 2023 Wodecki J +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Investigation of Electrical Bearing Failures
, 2023 Cette étude s'intéresse à l'effet des décharges capacitives, induites par les onduleurs d'alimentation des machines électriques, sur les roulements à billes. Un banc d'essai a été construit pour générer artificiellement une rugosité du roulement par électroérosion.
Jammoul, Sara +5 more
openaire +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source