Results 61 to 70 of about 998,913 (292)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Woven fabric carbon fibre composites hybrid joints under quasi-static testing [PDF]
, 2018 Twill weave carbon fibre reinforced polymer (CFRP) hybrid adhesively bonded-bolted joints was investigated on bearing stress at failure in experimental programmes. The present paper comprises effects of joint type, normalised coupon width (W/d), laminate
Ahmad, H., Lee, S.Y.
core +2 more sources
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Mobile- vs. Fixed-Bearing Total Ankle Prostheses
Foot & Ankle Orthopaedics, 2017 Category: Ankle, Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) is a well-accepted treatment option in patients with end-stage ankle osteoarthritis.
Alexej Barg MD +2 more
doaj +1 more source
Strength predictions of single-lap woven fabric Kenaf composites bolted joints
Journal of Mechanical Engineering and Sciences, 2020 Application of woven fabric kenaf fibers in production of polymeric composites (known as woven fabric kenaf reinforced composite (WKRP)) were readily available in the literatures due to excellent tensile strength and elongation at ...
H. Ahmad, K. Supar
doaj +1 more source
Failure analysis of superconducting bearings
Journal of Physics: Conference Series, 2006 The dynamics of superconductor bearings in a cryogenic failure scenario have been analyzed. As the superconductor warms up, the rotor goes through multiple resonance frequencies, begins to slow down and finally touches down when the superconductor goes through its transition temperature.
Amit Rastogi, A M Campbell, T A Coombs
openaire +1 more source
Predicting gearbox bearing failure [PDF]
, 2017 open3Cinquemani, Simone; Rosa, Francesco; Osto, EmanueleCinquemani, Simone; Rosa, Francesco; Osto ...
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Bearing behavior and failure mechanism of squeezed branch piles
Journal of Rock Mechanics and Geotechnical Engineering, 2018 The current practice for the design of squeezed branch piles is mainly based on the calculated bearing capacity of circular piles. Insufficient considerations of the load-transfer mechanism, branch effect and failure mechanism, as well as overreliance on
Minxia Zhang +3 more
doaj +1 more source