Results 61 to 70 of about 209,657 (314)

Experimental Study on the Mechanical Properties of CH4 and CO2 Hydrate Remodeling Cores in Qilian Mountain

Energies, 2017
The CH4-CO2 replacement method has attracted global attention as a new promising method for methane hydrate exploitation. In the replacement process, the mechanical stabilities of CH4 and CO2 hydrate-bearing sediments have become problems requiring ...
Tingting Luo, Yanghui Li, Weiguo Liu, Xiang Sun, Shi Shen   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Bearing Stress at Failure of Double-Lap Hybrid Joints in Woven Fabric Kenaf Fiber Composite Plates under Quasi-static Loading

MATEC Web of Conferences, 2017
The present paper is focused on the bearing stress at failure of double-lap woven fabric kenaf fiber reinforced polymer (KFRP) hybrid bonded-bolted joints in experimental frameworks.
Lee Sim Yee, Ahmad Hilton
doaj   +1 more source

Estimation on Reliability Models of Bearing Failure Data [PDF]

Mathematical Problems in Engineering, 2018
The failure data of bearing products is random and discrete and shows evident uncertainty. Is it accurate and reliable to use Weibull distribution to represent the failure model of product? The Weibull distribution, log-normal distribution, and an improved maximum entropy probability distribution were compared and analyzed to find an optimum and ...
Xia Xintao, Chang Zhen, Zhang Lijun, Yang Xiaowei   +3 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Electrostatic wear monitoring of rolling element bearings [PDF]

, 2007
Research and development work at the University of Southampton using an electrostatic condition monitoring system developed by Smiths Aerospace Information Systems has shown that electrostatic charge signals can be used to detect the onset of wear in ...
Harvey, T.J., Powrie, H.E.G., Wood, R.J.K.   +2 more
core   +1 more source

Mobile- vs. Fixed-Bearing Total Ankle Prostheses

Foot & Ankle Orthopaedics, 2017
Category: Ankle, Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) is a well-accepted treatment option in patients with end-stage ankle osteoarthritis.
Alexej Barg MD, Phinit Phisitkul MD, Charles Saltzman MD   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source