Results 61 to 70 of about 999,991 (257)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Mobile- vs. Fixed-Bearing Total Ankle Prostheses
Foot & Ankle Orthopaedics, 2017 Category: Ankle, Ankle Arthritis Introduction/Purpose: Total ankle replacement (TAR) is a well-accepted treatment option in patients with end-stage ankle osteoarthritis.
Alexej Barg MD +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Failure analysis of a graphite/epoxy laminate subjected to bolt bearing loads [PDF]
Quasi-isotropic graphite/epoxy laminates (T300/5208) were tested under bolt bearing loads to study failure modes, strengths, and failure energy. Specimens had a range of configurations to produce failures by the three nominal failure modes: tension ...
Crews, J. H., Jr., Naik, R. V. A.
core +1 more source
Avoiding negative depth in inverse depth bearing-only SLAM [PDF]
, 2008 In this paper we consider ways to alleviate negative estimated depth for the inverse depth parameterisation of bearing-only SLAM. This problem, which can arise even if the beacons are far from the platform, can cause catastrophic failure of the filter.We
Julier, SJ, Parsley, MP
core +1 more source
Predicting gearbox bearing failure [PDF]
, 2017 open3Cinquemani, Simone; Rosa, Francesco; Osto, EmanueleCinquemani, Simone; Rosa, Francesco; Osto ...
core
Experimental study and numerical modelling of woven fabric kenaf fiber composites hybrid adhesively bonded-bolted joints [PDF]
, 2018 Couple with natural fiber composite parts, hybrid joints provide better joint strength than using separate joints. There are limited studies on structures response and strength prediction work on hybrid joints that limits its applicability.
Lee, Sim Yee
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source