Results 51 to 60 of about 960,386 (297)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A Novel Cooperative Navigation Algorithm Based on Factor Graph and Lie Group for AUVs

Journal of Marine Science and Engineering
Traditional cooperative navigation algorithms for multiple AUVs are typically designed for a single specific configuration, such as parallel or leader-slave. This paper proposes a novel cooperative navigation algorithm based on factor graph and Lie group
Jiapeng Liu, Xiaodong Bu, Chao Wu
doaj   +1 more source

Mobile Bearing Total Knee Arthroplasty for Valgus Knee Osteoarthritis with Permanent Patellar Dislocation: A Case Report and Review of the Literature

Case Reports in Orthopedics, 2017
Permanent patellar dislocation with tibiofemoral joint osteoarthritis is a relatively rare condition. To treat this condition, total knee arthroplasty with proximal or distal realignment of the extensor mechanism has been reported.
Kohei Kamada, Tomoyuki Matsumoto, Koji Takayama, Daisuke Araki, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Ryosuke Kuroda   +7 more
doaj   +1 more source

In-Lab Demonstration of an Underwater Acoustic Spiral Source

Sensors, 2023
Underwater acoustic spiral sources can generate spiral acoustic fields where the phase depends on the bearing angle. This allows estimating the bearing angle of a single hydrophone relative to a single source and implementing localization equipment, e.g.,
Ruben Viegas, Friedrich Zabel, Antonio Silva   +2 more
doaj   +1 more source

Comparison of Mobile-Bearing and Fixed-Bearing Designs in High Flexion Total Knee Arthroplasty: Using a Navigation System

Knee Surgery & Related Research, 2012
We compared and analyzed the short term results of high flexion total knee arthroplasty (TKA) with mobile-bearing and fixed bearing designs.We studied 32 patients that had undergone TKA with LPS-Flex Mobile and 34 patients with LPS-Flex Fixed using an electromagnetic navigation system between January 2010 and June 2010, and were followed up for at ...
Kim, Tae Wan, Park, Shi Hwan, Suh, Jeung Tak   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Sensor fusion for interactive real-scale modeling and simulation systems [PDF]

, 2013
This paper proposes an accurate sensor fusion scheme for navigation inside a real-scale 3D model by combining audio and video signals. Audio signal of a microphone-array is merged by Minimum Variance Distortion-less Response (MVDR) algorithm and ...
CHARDONNET, Jean-Rémy, MIRZAEI, Mohammad Ali, PÈRE, Christian, Frederic Merienne, MERIENNE, Frédéric, M. Ali Mirzaei, Jean-Remy Chardonnet, Christian Pere   +7 more
core   +1 more source

A Decision Support System Using Fuzzy Logic for Collision Avoidance in Multi-Vessel Situations at Sea

Journal of Marine Science and Engineering, 2023
The increasing traffic and complexity of navigation at sea require advanced decision support systems to ensure greater safety. In this study, we propose a novel decision support system that employs fuzzy logic to improve situational awareness and to ...
Tanja Brcko, Blaž Luin
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source