Results 41 to 50 of about 35,550 (239)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impedance analysis and single ion channel recordings on pore-suspending lipid bilayers based on highly ordered pore arrays

, 2006
Ion channels are one of the main drug targets and are in the focus of various membrane biosensor applications and drug screening assays. The aim of this thesis was to develop and characterize a novel membrane system suspending highly ordered porous ...
Römer, Winfried
core   +1 more source

Organic field-effect transistors fabricated with N, N′ -substituted dialkyl-1,3,8,10-tetramethylquinacridone compounds [PDF]

, 2009
A series of robust and inexpensive p -type organic semiconductors 1,3,8,10-tetramethyl quinacridone compounds was prepared. These quinacridone compounds bearing N, N′ -disubstituted long N -alkyl chains self-organize into highly oriented crystalline ...
Xu, ZX, Wang, Y, Che, CM, Roy, V.A.L., Xiang, HF, Chui, SSY, Xu, Zong-Xiang, Hai-Feng Xiang, Lai, P.T., V. A. L. Roy, Wang, Yue, Che, Chi-Ming, Lai, PT, Chi-Ming Che, Chui, Stephen Sin-Yin, Zong-Xiang Xu, Roy, VAL, Xiang, Hai-Feng, Stephen Sin-Yin Chui, Yue Wang, P. T. Lai   +20 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Polyterthiophenes incorporating 3,4-difluorothiophene units : application in organic field-effect transistors [PDF]

, 2010
Two terthiophenes bearing core fluorinated thienyl units have been synthesised as potential semiconductor materials for organic field-effect transistors.
Martin Heeney, Iain McCulloch, McCulloch, Iain, Heeney, Martin, David J. Crouch, Skabara, Peter J., Peter J. Skabara, Skabara, Peter, Crouch, David J., Sparrowe, David, David Sparrowe   +10 more
core   +1 more source

Two-Mode Controlled Single/Dual-Input DC-AC Inverter with Wide-range DC Input

, 2021
This paper presents a two-mode controlled step-up inverter (TMCSI), which is capable of handling single or dual inputs with a wide range of dc input voltage.
Zhang, Zhe, Chen, Xuefeng
core   +1 more source

Some investigations on hybrid 3D printed PVDF-based functional prototypes

Next Materials
In the past decade, the polyvinylidene fluoride (PVDF) based composites processed by fused filament fabrication (FFF) and gel-printing routes have been widely used in various applications such as consumer products, pressure sensing, biomedical scaffolds,
Vinay Kumar, Gurwinder Singh, Minhaz Husain, Ranvijay Kumar, Harnarayan Meena, Rupinder Singh, MSJ Hashmi   +6 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Nonvolatile Bistable Resistive Switching in Polyimide Bearing Trifluoromethyl Film

, 2017
A functional polyimide (CF3 PI) was used as the active layer in our present work for electrical resistive memory device applications. Current–voltage ([Formula: see text]–[Formula: see text]) characteristics analysis on the polyimide memory devices ...
Enming Zhao, Yanmei Sun, Fengjuan Miao, Hui Li   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source