Results 101 to 110 of about 1,083,358 (272)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A brown bear population estimate for Finnmark County, North Norway

Fauna Norvegica
We have estimated the average number of brown bears Ursus arctos L. in Finnmark, the northernmost county in Norway. We started by estimating the number of bears where reproduction has been documented in the Pasvik Valley (1,330 km2) and published ...
Jon E. Swenson, Steinar Wikan
doaj   +1 more source

On the 3n+l Quantum Number in the Cluster Problem

, 1996
It has recently been suggested that an exactly solvable problem characterized by a new quantum number may underlie the electronic shell structure observed in the mass spectra of medium-sized sodium clusters. We investigate whether the conjectured quantum
A. Bohr, B. G. Wybourne, C. V. Sukumar, C. Yannouleas, Erik Koch, F. Cooper, H. Göhlich, H. Nishioka, J. E. Humphreys, J. Lermé, L. E. Gendenshtein, M. Brack, M. C. Gutzwiller, M. J. Englefield, N. Mukunda, O. Genzken, P. Stampfli, R. Balian, S. Bjørnholm, T. P. Martin, T. P. Martin, T. P. Martin, T. P. Martin, V. I. Arnold, V. M. Strutinsky, W. D. Knight, W. Ekardt, W. Fulton   +27 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Observations: bulls, bears, and ballclubs [PDF]

When professional sports teams go public.Professional ...
Matt Rutledge
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

More valuable dead than deterred? Crop‐raiding bears in Lao PDR

Wildlife Society Bulletin, 2014
Human–bear conflicts may contribute to population declines of Asiatic black bears (Ursus thibetanus) and sun bears (Helarctos malayanus) in Southeast Asia.
Lorraine Scotson, Kongseng Vannachomchan, Thomas Sharp   +2 more
doaj   +1 more source

The reception of Ernst Mach in the school of Brentano [PDF]

, 2018
This paper is about the reception of Ernst Mach by Brentano and his students in Austria. I shall outline the main elements of this reception, starting with Brentano’s evaluation, in his lectures on positivism, of Mach’s theory of ...
Fisette, Denis
core   +1 more source