Results 71 to 80 of about 1,083,358 (272)

Wild sun bears (Helarctos malayanus) exhibit aseasonality in parturition

open access: yesTheriogenology Wild
Seasonal reproduction can provide species with fitness advantages by allowing the birth of young to coincide with favorable environmental conditions, particularly in environments with high seasonal and intra-annual variation in these conditions. Seven of
Zachary A. David   +8 more
doaj   +1 more source

Portable Electric Fencing for Bear Deterrence and Conservation

open access: yesHuman-Wildlife Interactions, 2018
Although bear-inflicted (Ursus spp.) human fatalities are rare in North America, human injuries, property damage, and bear mortalities occur wherever bears and humans commingle.
Tom S. Smith   +3 more
doaj   +1 more source

Special mandrel permits uniform welding of out-of-round tubing [PDF]

open access: yes, 1966
Clamp holds irregularly shaped pieces in lathe chuck without damage and eliminates excessive time in selecting optimum mounting. Interchangeable jaws ride in standard jaw slots but swivel so that the jaw face bears evenly against the workpiece regardless
Dor, M. E., Fueg, L. B., Whiffen, E. L.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

"Goldilocks and the Three Bears" [PDF]

open access: yes
Unlike the Papa, Mama, and Baby Bears faced by the storybook Goldilocks, our Goldilocks faced three ferocious grizzlies: a cascading, global financial crisis; global deflation and excess capacity (or insufficient demand); and a domestic fiscal surplus in
L. Randall Wray
core  

The botnet: webs of hegemony/zombies who publish [PDF]

open access: yes, 2013
The scholarly communication structure at present bears a strong resemblance to a malware system called a botnet. This piece explores this metaphor and proposes ways in which the library can become a bi-directional information hub called the Research ...
Eve, Martin Paul
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Securing Pet Food from Florida Black Bears and Coyotes

open access: yesEDIS, 2018
The Florida black bear and the coyote are both prevalent throughout the state of Florida. The number one cause of human-wildlife conflict for these two species are food attractants, including pet food.
Kelley C Anderson   +1 more
doaj  

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