Advanced Science, EarlyView.High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
Reversible Horizontal Semicircular Canalith Jam Mimicking Acute Vestibular Syndrome: Diagnosis and Treatment with Head-Shaking and Gufoni Maneuvers. [PDF]
Turk Arch OtorhinolaryngolVats AK, Kothari S, Vundavilli P.
europepmc +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
Horizontal Semicircular Canal Benign Paroxysmal Positional Vertigo Presenting With Biphasic Nystagmus in the Healthy Ear-Down Position. [PDF]
CureusIchimura A.
europepmc +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source
Abattoir-Level Beef Cattle Handling and Its Impact on Meat Quality: A Comparative Analysis of Three Abattoirs of Eastern Amhara, Ethiopia. [PDF]
Vet Med IntAdane ST, Oumer E.
europepmc +1 more source
Bio‐Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors
Advanced Science, EarlyView.This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jae Yeong Jang, Hanchul Cho, Young Jung
wiley +1 more source
BioResourcesThe effects of laboratory beating on unbleached regular grade pine kraft pulp (UPKP), pre-treated with commercial cellulase/hemicellulase enzymatic preparation (C/HEP) were assessed using degrees of Schopper-Riegler (°SR) and fibre-quality numbers (FQN).
Dariusz Danielewicz
doaj
Automated processing pipeline for functional imaging of human cardiac organoids using optical coherence tomography. [PDF]
Biomed Opt ExpressLu K +6 more
europepmc +1 more source
Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, EarlyView.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source