Results 191 to 200 of about 14,223 (291)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro   +7 more
wiley   +1 more source

Beyond the mirror: the impact of mainstream beauty standards on diasporic caribbean women

open access: yes
LAUREA MAGISTRALEQuesta tesi indaga l'impatto degli standard di bellezza sull'identità personale, l'autostima e la rappresentazione culturale nella moda e nello spettacolo, con particolare attenzione alle donne latinoamericane e caraibiche.
Perez, Alianny Melina
core  

Med Spas: Patient Safety and Accreditation. [PDF]

open access: yesAesthet Surg J
Singer R, Jewell M, Saltz R, Fiala T.
europepmc   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

open access: yesAdvanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun   +15 more
wiley   +1 more source

Context matters: reconsidering resilience factors in dehumanization pathways to dysfunctional eating among transgender and gender diverse individuals. [PDF]

open access: yesFront Psychiatry
Bonato M   +8 more
europepmc   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

open access: yesAdvanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu   +10 more
wiley   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun   +27 more
wiley   +1 more source

Confronting Beauty Standards in Scott Westerfeld's 'Uglies

open access: yes
This study attempts to reveal the beauty standard concept that is confronted by the main character in Scott Westerfeld’s Uglies (2005) novel. It focuses on the issue of beauty standards criteria and the way the main character confronts it.
Siti Khodifatul Fauziah
core   +1 more source

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