Results 121 to 130 of about 5,752,788 (339)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

open access: yesMolecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués   +3 more
wiley   +1 more source

Becoming a distance student: Identifying and managing the key challenges [PDF]

open access: yes, 2018
Approximately 25% of first year, distance students are unsuccessful – they withdraw, fail or just give up on their study. They pay the fees but they don’t get the benefit. And they go away discouraged and disheartened.
Kahu, E
core  

Love and Redemption of Modern Man: Deleuzian and Sadraian “Becoming in Love”

open access: yesCritical Literary Studies
Modern Man, engaging the predicament of “identity” and “self”, seeks “love” as a redeeming power to reach affirmation of life and reconciliation. To discuss the issue, the concept of “becoming” as an innate motion and transformation in the process of ...
Seyedeh Solmaz Moosavi   +1 more
doaj   +1 more source

Alice oltre il selfie. Per essere degna di quel che le accade [PDF]

open access: yesLa Deleuziana, 2015
Alice’s becoming, as becoming simultaneously larger and smaller, provides the oppor-­‐‑ tunity to diagnose the present through a phenomenon more “current” than ever: Tiqqun’s “Jeune-­‐‑Fille” (young girl), which today is amplified by social networks.
Paolo Vignola
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Affective Practices in Transition(s)

open access: yesAS: Andragoška Spoznanja
This paper explores how affects shape life course transitions and processes of learning and becoming. Life transitions involve shifting self-world relations, changing social positions, and reconfiguring boundaries, which can be understood through ...
Anna Wanka
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Becoming and Belonging: Learning Qualitative Research Through Legitimate Peripheral Participation

open access: yesForum: Qualitative Social Research, 2003
Legitimate peripheral participation" (LPP) involves learning as a situated individual engages in socially mediated activity. We report on our attempt to use legitimate peripheral participation as a double normative frame for defining (a) a doctoral ...
Stuart Lee, Wolff-Michael Roth
doaj  

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