Results 201 to 210 of about 17,304 (263)

Hydrogels in the Management of Peripheral Venous Disease: Bridging Material Design and Clinical Evidence. [PDF]

Gels
Silosi CA, Silosi I, Ruscu MA, Rotaru-Zavaleanu AD.   +3 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It. [PDF]

Bioengineering (Basel)
Mosaid S, Jihad Y, Jihad M, Marudanayagam A, Lee P.   +4 more
europepmc   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Exercise-Induced Shear Stress, Endothelial Glycocalyx Remodeling, and Atherosclerotic Plaque Stability: A Mechanistic Review. [PDF]

J Cardiovasc Dev Dis
Qi Z, Zhang C, Shi H, Li W, Xia Y, Yan X, Zhou X, Ling J, Liu G.   +8 more
europepmc   +1 more source

Digital Design of Kurtosis-Controlled Ti-6Al-4V Lattices for Patient-Specific Orthopedic Implants: A Computational Framework. [PDF]

Bioengineering (Basel)
Sadenova M, Syrnev B, Azamatov B.
europepmc   +1 more source

Force-Chain Networks and Particle-Scale Mechanics of Granular Materials Under Low-Confinement Quasi-Static Shear. [PDF]

Materials (Basel)
Luo H, Zheng Y.
europepmc   +1 more source

Experimental and Numerical Investigations on Compressive Performance of Additively Manufactured PLA Structures with Various Infill Patterns. [PDF]

Polymers (Basel)
Llidó Barragán A, Unamuno Garay A, Ferrándiz-Bou S, Motoc DL, Pavón C.   +4 more
europepmc   +1 more source

How to Apply Positive-Reinforcement-Based Training for Self-Loading and Self-Unloading in Dromedary Camels. [PDF]

Animals (Basel)
Masebo NT, Faraz A, Angeloni MG, Saleem F, Buzdar HQ, Padalino B.   +5 more
europepmc   +1 more source