Results 171 to 180 of about 250 (214)

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

Animal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang, Shicheng Wan, Yanmin Guo, Hongyu Han, Fei Luo, Dongmei Jiang, Xiaorong Yang, Quanhai Pang, Haisheng Yu, Jinlian Hua   +9 more
wiley   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, EarlyView.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

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Effect of incoming sediment on the transport rate of bed load in mountain streams

International Journal of Sediment Research, 2009
Field experiments were conducted on bed load transport in the Diaoga River, a mountain stream in southwest China, to study the variation of bed load transport with varying sediment supply. The rate of bed load transport is greatly affected by incoming sediment (load and size). Under the same flow conditions, bed load transport rates may differ by three
Zhao-Yin Wang, Guoan Yu, Huaixiang Liu   +2 more
exaly   +2 more sources

Bed Load Grain Velocities and Sediment Transport Rates

Water Resources Research, 1984
Theoretical consideration of the dynamics of bed load sediment transport leads to expressions for bed grain velocity and sediment transport rate as, respectively, Ub = a(U* − U*c) and ib = (a/tan α) (U* − U*c) (т0−тc), agreeing in form with many previous analyses.
J. S. Bridge, D. F. Dominic
openaire   +1 more source

On the prediction of bed‐load sand transport rate in air

Sedimentology, 1994
ABSTRACTThis paper discusses the parameterization of aeolian mass transport rate beginning with a critical discussion of four different forms of the prediction equation. Following this, recent progress in understanding the physics of the aeolian system is used to suggest an alternative approach which provides some new insights into the prediction of ...
I. K. McEWAN, B. B. WILLETTS
openaire   +1 more source

Formulation of bed shear stress for computing bed-load transport rate in vegetated flows

Physics of Fluids, 2021
Difficulties are often encountered in estimating the bed shear stress in vegetated flows over a sediment bed due to complex interactions of the flow, sediment, and vegetation. Without involving any empirical partition of the bed friction and vegetation resistance, this study presents an analytical approach to evaluate the bed shear stress in the ...
Yesheng Lu, Nian-Sheng Cheng, Maoxing Wei   +2 more
openaire   +1 more source

Bed load transport rates during scouring and armoring processes

Journal of Mountain Science, 2010
Dambreak-induced bed scouring may undermine the foundation of bridge piers and other structures, and that destruction can pose a serious threat. Consequently, this paper aims at exploring the mechanisms of scouring and armoring. Firstly, the incipient velocity for nonuniform sediment particles was studied, and a formula was derived based on the angle ...
Fengguang Yang, Xingnian Liu, Shuyou Cao, Er Huang   +3 more
openaire   +1 more source

Morphological Estimation of the Time‐Integrated Bed Load Transport Rate

Water Resources Research, 1995
Recent research has suggested that given the problems associated with more conventional methods of estimating the bed load transport rate in dynamic rivers, measurement of the transfer of bed material, as indicated by changes in river channel form, may be an appropriate alternative.
S. N. Lane, K. S. Richards, J. H. Chandler   +2 more
openaire   +1 more source