Results 31 to 40 of about 152,455 (261)

Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk: Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity

Frontiers in Physiology, 2018
In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery disease and stroke is observed in healthy humans residing at high altitude in hypoxic environments ...
Gianni Biolo, Filippo G. Di Girolamo, Adam McDonnell, Nicola Fiotti, Filippo Mearelli, Roberta Situlin, Arianna Gonelli, Barbara Dapas, Mauro Giordano, Mitja Lainscak, Gabriele Grassi, Giorgio Zauli, Paola Secchiero, Igor Mekjavic   +13 more
doaj   +1 more source

The Physiology Associated With “Bed Rest” and Inactivity and How It May Relate to the Veterinary Patient With Spinal Cord Injury and Physical Rehabilitation

Frontiers in Veterinary Science, 2021
In the twentieth century, bed rest was commonly prescribed by human healthcare professionals as a treatment for a variety of ailments including spinal cord injury and disease.
Stephanie A. Thomovsky
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Reactive Jumps Preserve Skeletal Muscle Structure, Phenotype, and Myofiber Oxidative Capacity in Bed Rest

Frontiers in Physiology, 2020
Identification of countermeasures able to prevent disuse-induced muscle wasting is crucial to increase performance of crew members during space flight as well as ameliorate patient’s clinical outcome after long immobilization periods.
Dieter Blottner, Dieter Blottner, Maria Hastermann, Maria Hastermann, Robert Weber, Regina Lenz, Guido Gambara, Guido Gambara, Ulrich Limper, Ulrich Limper, Jörn Rittweger, Alessandra Bosutti, Hans Degens, Hans Degens, Michele Salanova, Michele Salanova   +15 more
doaj   +1 more source

Effects of 14 days of bed rest and following physical training on metabolic cost, mechanical work, and efficiency during walking in older and young healthy males. [PDF]

PLoS ONE, 2018
In this study, we investigated: i) the effects of bed rest and a subsequent physical training program on metabolic cost (Cw), mechanical work and efficiency during walking in older and young men; ii) the mechanisms underlying the higher Cw observed in ...
Mirco Floreani, Enrico Rejc, Paolo Taboga, Alessandro Ganzini, Rado Pišot, Bostjan Šimunič, Gianni Biolo, Carlo Reggiani, Angelina Passaro, Marco Narici, Joern Rittweger, Pietro Enrico di Prampero, Stefano Lazzer   +12 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

FROM SPACE FLIGHTS TO OSTEOPOROSIS

Annales Kinesiologiae, 2012
Space missions (microgravity) alter the balance between bone formation/resorption and induce bone loss. This effect represents a major limiting step in the realization of long-term space missions.
Giancarlo Bilancio, Cinzia Lombardi, Massimo Cirillo, Rado Pišot, Jörn Rittweger, Natale G. De Santo   +5 more
doaj  

Mitochondrial Adaptations in Elderly and Young Men Skeletal Muscle Following 2 Weeks of Bed Rest and Rehabilitation

Frontiers in Physiology, 2019
The aim of the study was to evaluate the expression levels of proteins related to mitochondrial biogenesis regulation and bioenergetics in vastus lateralis muscle biopsies from 16 elderly and 7 young people subjected to 14 days of bed-rest, causing ...
Alessia Buso, Marina Comelli, Raffaella Picco, Miriam Isola, Benedetta Magnesa, Rado Pišot, Joern Rittweger, Joern Rittweger, Desy Salvadego, Boštjan Šimunič, Bruno Grassi, Bruno Grassi, Irene Mavelli, Irene Mavelli   +13 more
doaj   +1 more source