Results 21 to 30 of about 5,384 (254)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Susceptibility of Flowers and Bedding Plants to Root-Knot Nematodes
EDIS, 2010 ENY-061, a 7-page illustrated fact sheet by Romy Krueger and Robert McSorley, summarizes recently published work on varying plant susceptibilities to root-knot nematodes and provides an overview of flower cultivars and their susceptibility to different ...
Romy Krueger, Robert McSorley
doaj +5 more sources
Biocontrol in practice in Canadian floricultural greenhouses
Ornamental Horticulture, 2021 The environment inside Canadian prairie greenhouses differs from greenhouses built in other northern latitude locations in terms of lighting, temperature, humidity, and photoperiod.
Poonam Singh, Tiffany Nykolyshyn
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Chemical growth retardants for bedding plants
California Agriculture, 1967 Chemical growth retardants placed on the market within the past few years have made it possible for bedding plant growers to reduce or eliminate excessive stem elongation, thereby producing a more compact and sturdier plant requiring less frequent ...
R Maire, R Sachs
doaj
Agronomy, 2021 Coal bottom ash (BA) is a by-product of coal-fired power generation and can be utilized as a growing substrate for ornamental plants. The physical and hydraulic properties of BA-mixed substrates (coir dust:BA, 10:0, 9:1, 8:2, 7:3, and 6:4, v/v) and ...
Yong-Ha Rhie, Suyun Nam, Jongyun Kim
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source