Results 1 to 10 of about 187,115 (300)

Microfluidic-Assisted ZIF-Silk-Polydopamine Nanoparticles as Promising Drug Carriers for Breast Cancer Therapy

Pharmaceutics, 2023
Metal–organic frameworks (MOFs) are heralded as potential nanoplatforms for biomedical applications. Zeolitic imidazolate framework-8 (ZIF-8), as one of the most well known MOFs, has been widely applied as a drug delivery carrier for cancer therapy ...
Zijian Gao, Muhamad Hawari Mansor, Natalie Winder, Secil Demiral, Jordan Maclnnes, Xiubo Zhao, Munitta Muthana   +6 more
doaj   +1 more source

HSV1716 Prevents Myeloma Cell Regrowth When Combined with Bortezomib In Vitro and Significantly Reduces Systemic Tumor Growth in Mouse Models

Viruses, 2023
Multiple myeloma remains largely incurable due to refractory disease; therefore, novel treatment strategies that are safe and well-tolerated are required.
Simon Tazzyman, Georgia R. Stewart, James Yeomans, Adam Linford, Darren Lath, Joe Conner, Munitta Muthana, Andrew D. Chantry, Michelle A. Lawson   +8 more
doaj   +1 more source

Macrophage Delivered HSV1716 Is Active against Triple Negative Breast Cancer

Future Pharmacology, 2022
Oncolytic viruses (OV) promote anti-tumour responses through the initiation of immunogenic cancer cell death which activates the host’s systemic anti-tumour immunity.
Amy Kwan, Faith Howard, Natalie Winder, Emer Atkinson, Ameera Jailani, Priya B. Patel, Richard Allen, Penelope D. Ottewell, Gary C. Shaw, Joe Conner, Caroline Wilson, Sanjay K. Srivastava, Sarah J. Danson, Claire Lewis, Janet E. Brown, Munitta Muthana   +15 more
doaj   +1 more source

Oncolytic Virotherapy Treatment of Breast Cancer: Barriers and Recent Advances

Viruses, 2021
Oncolytic virotherapy (OV) is an emerging class of immunotherapeutic drugs. Their mechanism of action is two-fold: direct cell lysis and unmasking of the cancer through immunogenic cell death, which allows the immune system to recognize and eradicate ...
Amy Kwan, Natalie Winder, Munitta Muthana   +2 more
doaj   +1 more source

Hellenic Beech Forests Database (Hell-Beech-DB) [PDF]

Biodiversity & Ecology, 2012
The Hellenic Beech Forests Database (GIVD ID EU-GR-007) includes releves dominated or co-dominated by Fagus sylvatica s.l. It includes almost all published releves from the northeast, north-central and east-central floristic regions of Greece. Ca. 50 unpublished releves have been already entered and more than 300 new releves are going to be entered ...
Tsiripidis, Ioannis, Bergmeier, Erwin, Fotiatidis, Georgios, Dimopoulos, Panayotis, Dengler, Jürgen   +4 more
openaire   +2 more sources

Effects of cannabis oil extract on immune response gene expression in human small airway epithelial cells (HSAEpC): implications for chronic obstructive pulmonary disease (COPD)

Journal of Cannabis Research, 2020
Background Chronic obstructive pulmonary disease (COPD) is commonly associated with both a pro-inflammatory and a T-helper 1 (Th1) immune response.
Stephen W. Mamber, Volkan Gurel, Jeremy Lins, Fred Ferri, Sarah Beseme, John McMichael   +5 more
doaj   +1 more source

Oestrogen and zoledronic acid driven changes to the bone and immune environments: Potential mechanisms underlying the differential anti-tumour effects of zoledronic acid in pre- and post-menopausal conditions

Journal of Bone Oncology, 2020
Late stage breast cancer commonly metastasises to bone and patient survival averages 2–3 years following diagnosis of bone involvement. One of the most successful treatments for bone metastases is the bisphosphonate, zoledronic acid (ZOL).
Christopher N. George, Victor Canuas-Landero, Elizavet Theodoulou, Munitta Muthana, Caroline Wilson, Penelope Ottewell   +5 more
doaj   +1 more source

How Could Sensor-Based Measurement of Physical Activity Be Used in Cardiovascular Healthcare?

Sensors, 2023
Physical activity and cardiovascular disease (CVD) are intimately linked. Low levels of physical activity increase the risk of CVDs, including myocardial infarction and stroke.
Megan E. Hughes, Timothy J. A. Chico
doaj   +1 more source

Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site

Molecules, 2021
Broad-spectrum cytotoxic drugs have been used in cancer therapy for decades. However, their lack of specificity to cancer cells often results in serious side-effects, limiting efficacy.
Mohammed S. Aldughaim, Fatimah Alsaffar, Michael D. Barker   +2 more
doaj   +1 more source

Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target

Cells, 2020
Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in ...
Jiepei He, Yuhan Zhou, Hector M. Arredondo Carrera, Alexandria Sprules, Ramona Neagu, Sayyed Amin Zarkesh, Colby Eaton, Jian Luo, Alison Gartland, Ning Wang   +9 more
doaj   +1 more source