Results 161 to 170 of about 55,797 (269)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

Advanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin, Ruiling Xu, Meagan J. Makarczyk, Jia‐Jun Liu, Silvia Liu, Matthew Z. Shi, Roberta Di Carlo, Michael F. Almeida, Alex Garris, Sarah Day, Rebekah Sanchez‐Hodge, Jonathan C. Schisler, Aleeza H. Zilberman, Noah G. Allen, Angela J. Kubik, Elizabeth A. Blaber, Arnold Z. Olali, Wanqing Xie, Douglas C. Wallace, Christopher E. Mason, Peter G. Alexander, Giuseppe Intini, Afshin Beheshti, Hang Lin   +23 more
wiley   +1 more source

MicroRNA-281-X Modulates Self-Grooming Behavior in Honeybees by Targeting Tyrosine Decarboxylase 2 in the Octopaminergic Pathway. [PDF]

Insects
Lü Y, Ouyang W, Liao J, Miao L, Li Z, Su S.   +5 more
europepmc   +1 more source

Mechanical Flexibility Enables DNA Origami to Overcome Steric Confinement in Mucus

Advanced Science, EarlyView.
Mechanical flexibility is introduced as a design parameter to enhance nanocarrier transport in mucus. Using DNA origami, flexibility is decoupled from size, shap and surface chemistry, revealing improved passage through confined hydrogel networks. While surface passivation reduces aggregation, flexibility further boosts transport, offering a general ...
Matteo Tollemeto, Emily Tsang, Marie Karen Tracy Hong Lin, Luca Mannino, Kurt V. Gothelf, Anja Boisen   +5 more
wiley   +1 more source

Testing Bottom-up Cuing Effects on Target Detection and Discrimination in Bumblebees. [PDF]

J Insect Behav
Robert T, Callendret M, Sowels C, Nityananda V.   +3 more
europepmc   +1 more source

Emergent 3D Fermiology and Magnetism in an Intercalated Van der Waals System

Advanced Science, EarlyView.
An emergent three‐dimensional electronic state is uncovered in an intercalated van der Waals system. A spin‐polarized intercalant‐host hybridized band crossing the Fermi level provides an itinerant channel for interlayer exchange, highlighting how electronic dispersion governs magnetic dimensionality.
Luigi Camerano, Emanuel A. Martínez, Victor Porée, Laura Martella, Dario Mastrippolito, Debora Pierucci, Franco D'Orazio, Polina M. Sheverdyaeva, Paolo Moras, Enrico Della Valle, Tianlun Yu, Moritz Hoesch, Craig M. Polley, Thiagarajan Balasubramanian, Alessandro Nicolaou, Luca Ottaviano, Vladimir N. Strocov, Gianni Profeta, Federico Bisti   +18 more
wiley   +1 more source

Protein craving links larval signals to food provisioning in honey bees. [PDF]

Sci Adv
Li Z, Wu Y, Liu J, Yang C, Wang S, Huang M, Luo S, Zhou X.   +7 more
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Gut microbiota of Brazilian Melipona stingless bees: Dominant members and their localization in different gut regions. [PDF]

PLoS One
Santini AT, Cerqueira AES, Moran NA, Resende HC, Santana WC, de Paula SO, da Silva CC.   +6 more
europepmc   +1 more source

Development and Applications of a Magnetism‐Aware General‐Purpose Atomic Cluster Expansion Potential for the Fe‐O‐H Ternary System

Advanced Science, EarlyView.
Hydrogen‐driven iron oxide reduction, water‐iron corrosion, and hydrogen embrittlement of metallic iron share the same Fe‐O‐H chemistry. A general‐purpose Atomic Cluster Expansion potential covers this chemistry across the full concentration range with explicit Ising‐like treatment of magnetism.
Baptiste Bienvenu, Mira Todorova, Jörg Neugebauer, Dierk Raabe, Matous Mrovec, Ralf Drautz   +5 more
wiley   +1 more source

Assessing spinosad effect on honey bee olfactory conditioning using a microcontroller-based device. [PDF]

Front Insect Sci
Rondoni G, Napoli F, Chierici E, Conti E.   +3 more
europepmc   +1 more source