Results 111 to 120 of about 2,961,171 (300)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Laudatio: Ad multos annos dear Zoltán Majó!

open access: yesStudia Universitatis Babeş-Bolyai. Musica, 2019
I have often said before that according to biblical time, the age of 60 years is the end of the first half and the beginning of the second half of human life, as it is also stated in Genesis 6.
János MOLNÁR
doaj   +2 more sources

Population and Inequality in East Asia [PDF]

open access: yes
This paper describes the inequality experience of East Asia beginning around 1960 and explores whether that experience is consistent with alternative theories about the determinants of income inequality.
Andrew Mason, Harry Oshima
core  

Adolescence, Puberty, And Propensity For Sexual Activeness: Implication For Supportive Counselling Intervention [PDF]

open access: yes, 2013
Adolescence as an season of life interesting to observe or experience, is characterized by and synonymous to puberty; beginning at the end ofchildhood, and spanning the entire teenage years. At puberty, adolescence maturation indices falsely projects
Evbuoma, I. K.
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

Personal identity and bioethical issues in the vicinity

open access: yesАктуальні проблеми духовності
The article discusses the relationship between the concept and philosophical theories of personal identity on one hand and bioethical problems on the other.
Dmytro Sepetyi
doaj   +1 more source

Space Human Factors Engineering Gap Analysis Project Final Report [PDF]

open access: yes, 2006
Humans perform critical functions throughout each phase of every space mission, beginning with the mission concept and continuing to post-mission analysis (Life Sciences Division, 1996).
Hudy, Cynthia, Woolford, Barbara
core   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela   +13 more
wiley   +1 more source

Human Wisdom, Studies in Ancient Greek Philosophy [PDF]

open access: yes, 2016
This book offers inter alia a systematic investigation of the actual argumentative strategy of Socratic conversation and explorations of Socratic and Platonic morality including an examination ofeudaimonia and the mental conception of health in the ...
Erik, Ostenfeld
core  

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