Results 111 to 120 of about 2,961,171 (300)
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Laudatio: Ad multos annos dear Zoltán Majó!
I have often said before that according to biblical time, the age of 60 years is the end of the first half and the beginning of the second half of human life, as it is also stated in Genesis 6.
János MOLNÁR
doaj +2 more sources
Population and Inequality in East Asia [PDF]
This paper describes the inequality experience of East Asia beginning around 1960 and explores whether that experience is consistent with alternative theories about the determinants of income inequality.
Andrew Mason, Harry Oshima
core
Adolescence, Puberty, And Propensity For Sexual Activeness: Implication For Supportive Counselling Intervention [PDF]
Adolescence as an season of life interesting to observe or experience, is characterized by and synonymous to puberty; beginning at the end ofchildhood, and spanning the entire teenage years. At puberty, adolescence maturation indices falsely projects
Evbuoma, I. K.
core
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Personal identity and bioethical issues in the vicinity
The article discusses the relationship between the concept and philosophical theories of personal identity on one hand and bioethical problems on the other.
Dmytro Sepetyi
doaj +1 more source
Space Human Factors Engineering Gap Analysis Project Final Report [PDF]
Humans perform critical functions throughout each phase of every space mission, beginning with the mission concept and continuing to post-mission analysis (Life Sciences Division, 1996).
Hudy, Cynthia, Woolford, Barbara
core +1 more source
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
Human Wisdom, Studies in Ancient Greek Philosophy [PDF]
This book offers inter alia a systematic investigation of the actual argumentative strategy of Socratic conversation and explorations of Socratic and Platonic morality including an examination ofeudaimonia and the mental conception of health in the ...
Erik, Ostenfeld
core

