Results 71 to 80 of about 10,531,467 (204)

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

When to consider an inborn error of immunity: clues for physicians

Internal Medicine Journal, EarlyView.
Abstract The term inborn errors of immunity (IEIs) refers to the rapidly expanding group of genetic disorders causing dysregulation of the immune system. With improved genetic testing in recent years, the number of defined IEIs and their range of phenotypic presentations has grown vastly, with more than 550 IEIs now described.
Meera Thangarajah, Lucinda J. Berglund
wiley   +1 more source

Delphi consensus: First‐line use of biologics and small molecules in hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This Delphi Consensus study identified upgrade criteria for the use of biologics and small molecules as first‐line therapy in hidradenitis suppurativa (HS). European HS experts evaluated 16 clinical scenarios, voting on eligibility for therapy escalation.
Georgios Nikolakis, Erkan Alpsoy, Florian Anzengruber, Matthias Augustin, Falk G. Bechara, Pierre‐André Becherel, Farida Benhadou, Vincenzo Bettoli, Joana Cabete, Raffaele Dante Caposiena Caro, Antonella Di Cesare, Giovanni Damiani, Valentina Dini, Evangelos J. Giamarellos‐Bourboulis, Krisztián Gáspár, Katalin Glasenhardt, Philippe Guillem, Ariela Hafner, Barbara Horvath, John R. Ingram, Vaiva Jarienè, Gregor B. E. Jemec, Alexander Katoulis, Natalia Kirsten, Georgios Kokolakis, Piotr K. Krajewski, Aikaterini I. Liakou, Flavia Manzo Margiotta, Angelo V. Marzano, Antonio Martorell, Lukasz Matusiak, Dillon Mintoff, Alejandro Molina Leyva, Andreas Pinter, Anna Pirogova, Maurizio Podda, Francesca Prignano, Jorge Romani, Marco Romanelli, Elia Rosi, Samed Sahin, Ditte M. L. Saunte, Sylke Schneider‐Burrus, Mariano Suppa, Jacek Szepietowski, Andrea Szegedi, Simon Francis Thomsen, Thrasyvoulos Tzellos, Anastasia Trigoni, Hessel H. Van Der Zee, Kelsey Van Straalen, Skaidra Valiukevičiene, Eva Vilarrasa, Esther von Stebut, Christos C. Zouboulis   +54 more
wiley   +1 more source

Bimekizumab efficacy using IHS4 outcomes in hidradenitis suppurativa: Results from BE HEARD I and II

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The majority of bimekizumab‐treated patients shifted from severe to mild and moderate IHS4 stages, and nearly 25% achieved an IHS4 of 0 by Week 48. Bimekizumab led to clinically meaningful improvements across IHS4 outcome measures. These data highlight an opportunity to address the need for effective treatments against draining tunnels.
Thrasyvoulos Tzellos, Evangelos J. Giamarellos‐Bourboulis, Kelsey R. van Straalen, Antonio Martorell, Brian Kirby, Afsaneh Alavi, Koremasa Hayama, Saakshi Khattri, Wayne Gulliver, Christopher J. Sayed, Leah Davis, Robert L. Rolleri, Christina Crater, Ingrid Pansar, Jérémy Lambert, Christos C. Zouboulis   +15 more
wiley   +1 more source

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behçet's Disease: National Multicenter Study of 177 Cases

Arthritis & Rheumatology, 2019
To compare the efficacy of infliximab (IFX) versus adalimumab (ADA) as a first‐line biologic drug over 1 year of treatment in a large series of patients with refractory uveitis due to Behçet's disease (BD).
B. Atienza-Mateo, J. Martín-Varillas, V. Calvo-Río, R. Demetrio-Pablo, E. Beltrán, J. Sánchez-Bursón, M. Mesquida, A. Adán, M. Hernández, M. Hernández-Garfella, E. Valls-Pascual, L. Martínez-Costa, A. Sellas-Fernández, M. Cordero‐Coma, M. Díaz‐Llopis, R. Gallego, J. L. García-Serrano, N. Ortego-Centeno, J. Herreras, A. Fonollosa, Á. García-Aparicio, O. Maíz-Alonso, A. Blanco, I. Torre-Salaberri, C. Fernández-Espartero, V. Jovaní, D. Peiteado, E. Pato, J. Cruz, C. Fernández-Cid, E. Aurrecoechea, M. García-Arias, S. Castañeda, M. A. Caracuel-Ruiz, C. Montilla-Morales, A. Atanes-Sandoval, F. Francisco, S. Insúa, S. González-Suárez, A. Sánchez-Andrade, F. Gamero, L. F. Linares Ferrando, F. Romero-Bueno, A. J. García-González, R. González, E. M. Muro, C. Carrasco-Cubero, A. Olivé, Á. Prior, J. Vázquez, Ó. Ruiz-Moreno, Fernando Jiménez-Zorzo, J. Manero, S. Muñoz Fernández, C. Fernández-Carballido, E. Rubio-Romero, F. Pages, F. Toyos-Sáenz de Miera, Myriam Gandía Martinez, D. Díaz-Valle, F. J. Lopez Longo, J. Nolla, E. Álvarez, Marcelino Martínez, J. González-López, P. Rodríguez-Cundín, J. Hernández, M. González-Gay, R. Blanco   +68 more
semanticscholar   +1 more source

Measuring success in HS treatment from the physician's and the patient's perspective

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Integrated clinician (HiSCR, IHS4, IHS4‐55, HS‐IGA) and patient (HiSQOL, DLQI) scores, combined with imaging‐based fibrosis and inflammation assessment, redefine treatment success in hidradenitis suppurativa by aligning treat‐to‐target strategies with both inflammatory control and irreversible structural damage.
Georgios Nikolakis, Monika Arenbergerova, Zeljko Mijuskovic, Baoxi Wang, Christos C. Zouboulis   +4 more
wiley   +1 more source

Effectiveness of a blood culture bundle in reducing contamination rates in a neonatal intensive care unit

The Turkish Journal of Pediatrics
Background. Isolating microorganisms from blood cultures is the gold standard for identifying the cause of sepsis. However, contamination of the blood culture is a significant barrier to the blood culture’s utility.
Şebnem Çalkavur, Oğuz Han Kalkanlı, Tuna Ketenci, Nazan Kavas, Miray Yılmaz Çelebi, Arzu Bayram, İlker Devrim   +6 more
doaj   +1 more source

Improved Efficiency and Lesion Detection in Small Bowel Capsule Endoscopy Using the Open‐Source Artificial Intelligence Model SEE‐AI

DEN Open, Volume 7, Issue 1, April 2027.
AI‐assisted reading with the open‐source SEE‐AI model improves lesion detection sensitivity and reduces reading time in small‐bowel capsule endoscopy. In a multicenter retrospective study of 249 cases, SEE‐AI provides visual cues that support physicians during interpretation while preserving physician‐led final decisions.
Satoshi Miyazono, Junji Umeno, Tomohiro Nagasue, Takuto Saiki, Hisamitsu Kaku, Takehiro Torisu, Akihito Yokote, Keisuke Kawasaki, Yutaro Ihara, Yuichi Matsuno, Noriyuki Imazu, Tomohiko Moriyama, Ahmed Nashaat Mohamed, Katsuya Hirakawa, Hajime Yamagata, Yasuharu Okamoto, Koichi Kurahara, Shinichiro Yada, Akira Harada, Tetsuro Ago   +19 more
wiley   +1 more source

Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double‐Blind Trial

Pain Practice, Volume 26, Issue 7, September 2026.
ABSTRACT Background Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients.
Philippe Lafuma, Laurent Magaud, Amna Abichou‐Klich, Muriel Rabilloud, Julien Wegrzyn, Christian Baude, Pascal Rippert, Myriam Kaou, Julie Haesebaert, Frédéric Rongieras, Chloé Marchand, Carole Dhelens, Olivia Febvey‐Combes   +12 more
wiley   +1 more source

The Effect of Caregiver Burden on Healthy Lifestyle Behaviours of People Caring for Patients With Alzheimer's Disease: A Cross‐Sectional Study

Scandinavian Journal of Caring Sciences, Volume 40, Issue 3, September 2026.
ABSTRACT Objectives This study aimed to determine the effects of caregiver burden on the healthy lifestyle behaviours of people caring for patients with Alzheimer's disease. Methods The Caregiver Burden Inventory (CBI) and the Healthy Lifestyle Behaviour Scale‐II (HLBS‐II) were administered to caregivers of Alzheimer's disease patients who were ...
Büşra Neva Tekin, Sıdıka Kaya, Nigar Esra Erkoç Ataoğlu, Mesut Teleş   +3 more
wiley   +1 more source