Results 221 to 230 of about 1,858,978 (284)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Translational Perspectives on Binge-Eating: Insights from Animal Models. [PDF]

Curr Psychiatry Rep
Azevedo EP, Stern SA.
europepmc   +1 more source

Animal behavior

, 1970
Buser, P., Cook, L., Giurgea, C., Jacobsen, E., Ray, O. S., Richelle, Marc, Silverman, A. P., Stein, L., Votava, Z.   +8 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

An overview of the benefits of animal-assisted interventions in medical and therapeutic contexts for human health: cognitive mechanisms, sensory perception and welfare considerations. [PDF]

Front Vet Sci
Mota-Rojas D, Nannoni E, Strappini AC, Hernández-Avalos I, Martínez-Burnes J, Domínguez-Oliva A, Mora-Medina P, Abd El-Aziz AH, Olmos-Hernández A, Miranda-Cortes A, Casas-Alvarado A, Torres-Bernal F, Grandin T.   +12 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Effects of maternal appeasing substance and castration status on growth performance and health in newly received, high-risk beef calves. [PDF]

Transl Anim Sci
Cheek RA, Johnston E, Whittle R, Reynolds J, Galloway D, Kegley EB, Powell JG, Weimer S.   +7 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Post-transport recovery trajectory of the canine gut microbiome and metabolome. [PDF]

J Anim Sci Biotechnol
Lyu Y, Su C, Sun K, Wang Y, Zhang L, Pu J, Wu C, Thomas D, Che L.   +8 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source