A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
The Relationship Between Harsh Parenting and Adolescents' Pro-Environmental Behavior: A Moderated Mediation Model. [PDF]
Psychol BelgWang D, Wei S, Mao W, Lu Z, Hu Y.
europepmc +1 more source
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
The effect of doll blind box uncertainty on consumers' irrational consumption behavior: the role of instant gratification, Gambler's fallacy, and perceived scarcity. [PDF]
BMC PsycholXia F, Xu Y, Zhang H, Yuan X.
europepmc +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
How does team reflexivity affect new generation employee cooperative behavior in China? A cross-level moderated mediation model. [PDF]
Front PsycholLi Y, Li H, Xiao Y.
europepmc +1 more source
FEBS Open Bio, EarlyView.We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang +7 more
wiley +1 more source
Trends of inequities in healthcare seeking behavior for diarrhea, fever, and ARI symptoms among women in reproductive age groups for their under-five children in Ethiopian: A multilevel Analysis of EDHS Surveys from 2000 to 2016. [PDF]
PLoS OneFekadu H +4 more
europepmc +1 more source