Results 201 to 210 of about 6,192,922 (341)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Facilitate behavior change among surgeons for infection prevention and stewardship: lessons learned from Asia. [PDF]
Antimicrob Steward Healthc EpidemiolApisarnthanarak A, Rukskul P, Mundy LM.
europepmc +1 more source
Changes in expenditures for Medicaid enrollees with a behavioral health diagnosis: 2005-2010
, 2015 John Robst
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Physical Therapists' Use of Behavior Change Strategies to Promote Physical Activity for Individuals with Neurological Conditions. [PDF]
Healthcare (Basel)LaMarca A, Larsen G, Lyons KD, Keysor J.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Behavioral science meets public health: a scoping review of the fogg behavior model in behavior change interventions. [PDF]
BMC Public HealthDuarte-Anselmi G +3 more
europepmc +1 more source
Modeling of Sediment Behavior on Urban Watershed and Determination of Climate Change Effects [PDF]
, 2013 Burcu Şimşek Uygun, Mine Albek
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source