Results 221 to 230 of about 2,436,106 (292)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout Mice. [PDF]

Eur J Neurosci
Witt EA, Stanton-Turcotte D, Garay P, Ge J, Iulianella A.   +4 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Action information is integrated into entorhinal representations of conceptual space and is reflected in eye movements. [PDF]

PLoS Biol
Eperon A, Doeller CF, Theves S, Bottini R.   +3 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner. [PDF]

Transl Psychiatry
Byun S, Sotzen MR, Knappenberger MA, Olekanma DI, Bento M, Skibicka KP.   +5 more
europepmc   +1 more source

Exploring medication adherence and illness perception in patients with neuroimmune diseases: a cross-sectional study. [PDF]

Front Immunol
Fu R, Wang X, Shi Z, Wang R, Zhou H.
europepmc   +1 more source

Dual denoising contrastive learning with multi-interest fusion for sequential recommendation. [PDF]

Sci Rep
Long H, Lu J, Dai C.
europepmc   +1 more source