Results 271 to 280 of about 11,021,950 (406)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Cognitive behavior therapy for academic burnout, procrastination, self-handicapping behavior, and test anxiety among adolescents: a randomized control trial. [PDF]

BMC Psychol
Khurshid K, Mushtaq R, Rauf U, Anwar N, Abbas Q, Aljhani S, Ramzan Z, Shahzadi M.   +7 more
europepmc   +1 more source

Recovery of ovarian activity in women with functional hypothalamic amenorrhea who were treated with cognitive behavior therapy [PDF]

, 2003
Sarah L. Berga, Marsha D. Marcus, Tammy L. Loucks, Stefanie A. Hlastala, Rebecca Ringham, Marijane A. Krohn   +5 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A dialectical behavior therapy skills training smartphone app for recurrent binge eating: a randomized clinical trial. [PDF]

Psychol Med
Linardon J, Anderson C, McClure Z, Liu C, Messer M, Jarman HK, Fuller-Tyszkiewicz M.   +6 more
europepmc   +1 more source

Behavior Therapy for Families of Adolescents With Diabetes

, 2001
Tim Wysocki, Peggy Greco, Michael A. Harris, Jeannie Bubb, Neil H. White   +4 more
openalex   +1 more source

Cognitive–Behavioral Therapy for Chronic Low Back Pain in Older Persons: A Preliminary Study [PDF]

, 2003
M. Carrington Reid, John D. Otis, Lisa C. Barry, Robert D. Kerns   +3 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Predicting treatment response to cognitive behavior therapy in social anxiety disorder on the basis of demographics, psychiatric history, and scales: A machine learning approach. [PDF]

PLoS One
Bukhari Q, Rosenfield D, Hofmann SG, Gabrieli JDE, Ghosh SS.   +4 more
europepmc   +1 more source

COGNITIVE BEHAVIORAL GROUP THERAPY IMPROVES QUALITY OF LIFE MORE THAN GENERAL HEALTH EDUCATION FOR ANXIETY IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE [PDF]

, 2003
Sylvia Adams, Tamara Simpson, Patrick F. Allan, Shuko Lee, Gilbert A. Vipraio, Paulla K. Smith, Antonio Anzueto, Jacqueline A. Pugh, Lisa K. Kearney   +8 more
openalex   +1 more source