Results 61 to 70 of about 2,827,572 (302)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The relationship between behavioral activation and burnout in a community setting: the mediating role of acceptance-based action, automatic negative thought, and self-efficacy

Frontiers in Psychology
IntroductionBurnout, a work-related syndrome, considerably overlaps with depression. Despite its negative impact on modern society, the underlying mechanisms and effective interventions remain unclear.
Hyewon Yeo, Jini Tae, Yoonhyoung Lee, Youngeun Kim, Wonhye Lee   +4 more
doaj   +1 more source

Motivational and Behavioral Activation as an Adjunct to Psychiatric Rehabilitation for Mild to Moderate Negative Symptoms in Individuals with Schizophrenia: A Proof-of-Concept Pilot Study

Frontiers in Psychology, 2016
Few psychosocial approaches address the negative symptoms of schizophrenia, which shares common features with depression and anxiety. Behavioral activation (BA) is effective for addressing depression and anxiety in adults with various mental disorders ...
Kee-Hong Choi, Eunju Jaekal, Ga-Young Lee   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Feasibility randomized controlled trial of cognitive and behavioral interventions for depression symptoms in patients accessing drug and alcohol treatment [PDF]

, 2015
Depressed mood often co-exists with frequent drug and alcohol use. This trial examined the feasibility of screening, recruitment, randomization and engagement of drug and alcohol users in psychological interventions for depression symptoms. A total of 50
Delgadillo, J., Gilbody, Simon, Gore, Stuart, Ekers, D., Gilchrist, G., Delgadillo, Jaime, Ekers, David, Hughes, E., McMillan, D., Gilchrist, Gail; id_orcid, McMillan, Dean, Ali, Shehzad, Gilbody, S., Hughes, Elizabeth, Ali, S., Gilchrist, Gail, Gore, S.   +16 more
core   +1 more source

Impacts and Pathways of Behavioral Activation on Psychological Distress Among Patients Diagnosed With Esophageal and Gastric Cancer in China: A Randomized Controlled Trial

Cancer Medicine
Objective The objective of this study is to investigate the efficacy of behavioral activation (BA), a novel psychological intervention, in ameliorating psychological distress and anxiety symptoms among patients diagnosed with esophageal and gastric ...
Runze Huang, Anlong Li, Han Ge, Lijun Liu, Ling Cheng, Mingjun Zhang, Huaidong Cheng   +6 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Implementing Behavioral Activation in Geriatric Depression: A Primer

, 2022
Behavioral activation (BA) is a psychosocial treatment for depression designed to help patients increase contact with positive and rewarding aspects of daily life. The majority of BA research has focused on general adults and adolescents.
R. Hershenberg, O.M. Glass
core   +1 more source

Activism, Event and the Transmission of Behavior: Designing With Behavior for Behavior

, 2011
In Helsinki, summer 2010, a group of friends challenged each other to just consume at local independent stores for two weeks long. This challenge became an event of public calling for controversy, rallying support for small independent shop owners, in opposition to large retail chains.
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source