Results 291 to 300 of about 284,658 (331)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

open access: yesAdvanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio   +11 more
wiley   +1 more source

A community-driven approach to address substance use and create a Great Plains American Indian addiction and recovery research agenda. [PDF]

open access: yesAm J Community Psychol
Luger B   +8 more
europepmc   +1 more source

Behavioral addictions

Current Opinion in Neurobiology, 2015
Behavioral addictions are slowly becoming recognized as a valid category of psychiatric disorder as shown by the recent allocation of pathological gambling to this category in DSM-5. However, several other types of psychiatric disorder proposed to be examples of behavioral addictions have yet to be accorded this formal acknowledgment and are dispersed ...
T W, Robbins, L, Clark
  +7 more sources

Behavioral addictions

2022
Abstract Behavioral (or process) addictions, which are defined as addictions when an individual repeatedly engages in a behavior that leads to negative effects on the their ability to function normally in daily life and has a deleterious effect on the person’s overall health. Core features of behavioral addictions are similar to symptoms
Attila Szabo, Zsolt Demetrovics
  +4 more sources

Behavioral Addictions

Pediatric Clinics of North America, 2019
Certain centrally acting chemicals, such as cocaine or amphetamine, affect the brain’s reward pathways, particularly the nucleus accumbens “reward center” and linked dopamine and opioid systems. Repeated consumption of such substances, for vulnerable individuals, can lead to escalating cycles of intake and functional impairment, termed addiction ...
Chamberlain, Samuel R., Grant, Jon E.
  +5 more sources

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