Results 61 to 70 of about 2,340,151 (253)

Internet Gaming Disorder and the DSM-5: Conceptualization, Debates, and Controversies [PDF]

, 2015
Scientific interest in behavioral addictions (such as Internet gaming disorder [IGD]) has risen considerably over the last two decades. Moreover, the inclusion of IGD in Section 3 of DSM-5 will most likely stimulate such research even more.
Demetrovics, Zsolt, Zsolt Demetrovics, Király, Orsolya, Griffiths, Mark D., Griffiths, MD, Mark D. Griffiths, Király, O, Demetrovics, Z, Orsolya Király   +8 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Feather picking in pet parrots: sensitive species, risk factor and ethological evidence

Italian Journal of Animal Science, 2016
The goals of this study were to estimate the prevalence of feather picking (FP) in Italian pet parrots and evaluate the risk factors and possible ethological correlation.
Pierluca Costa, Elisabetta Macchi, Laura Tomassone, Fulvio Ricceri, Enrico Bollo, Frine Eleonora Scaglione, Martina Tarantola, Michele De Marco, Liviana Prola, Domenico Bergero, Achille Schiavone   +10 more
doaj   +1 more source

Parent and self-report health-related quality of life measures in young patients with Tourette syndrome [PDF]

, 2013
Tourette syndrome is a neurodevelopmental disorder characterized by tics and comorbid behavioral problems. This study compared child- and parent-reported quality of life and everyday functioning.
C. Luoni, C. Selvini, A. E. Cavanna, Blangiardo, R, Cali', PV, Blangiardo, Rosanna, CARDONA, Francesco Carmelo Giovanni, Rizzo, R, TERMINE, CRISTIANO, Eddy, Clare M, Selvini, Claudia, Cardona, Francesco, Gagliardi, E, SILVESTRI, PAOLA ROSARIA, U. Balottin, Silvestri, Paola R., BALOTTIN, UMBERTO, E. Gagliardi, Cardona, F, Cavanna, Andrea E., Gagliardi, Emanuela, Cali', Paola V., Cavanna, Andrea E; id_orcid, Cavanna, AE, Eddy, CM, Balottin, U, C. M. Eddy, P. V. Cali', Silvestri, Paola R, Luoni, C, Termine, C, Eddy, Clare M., Rizzo, Renata, C. Termine, Silvestri, PR, R. Blangiardo, Cali', Paola V, R. Rizzo, Luoni, Chiara, Selvini, C   +39 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Managing the Issue of School Deviance [PDF]

Ovidius University Annals: Economic Sciences Series, 2019
School deviance is a current phenomenon and, unfortunately, of great complexity, a problem that cannot be eradicated and will only disappear through the involvement of the school as a form of institutionalized mass education.
Timeea-Alexandra Simionescu (Savu)
doaj  

MAP Kinase Signaling Cascade Dysfunction Specific to Alzheimer's Disease in Fibroblasts

Neurobiology of Disease, 2002
Mitogen-activated protein kinases (such as Erk1/2) regulate phosphorylation of the microtubule-associated protein tau and processing of the amyloid protein β, both events critical to the pathophysiology of Alzheimer's disease (AD).
Wei-Qin Zhao, Lakshmi Ravindranath, Ali S. Mohamed, Ofer Zohar, Gina H. Chen, Constantine G. Lyketsos, René Etcheberrigaray, Daniel L. Alkon   +7 more
doaj   +1 more source

CRF serum levels differentiate PTSD from healthy controls and TBI in military veterans

Psychiatric Research and Clinical Practice, 2021
Background and Objective Posttraumatic stress disorder (PTSD) is a serious and frequently debilitating psychiatric condition that can occur in people who have experienced traumatic stressors, such as war, violence, sexual assault and other life ...
Jaime Ramos‐Cejudo, Afia Genfi, Duna Abu‐Amara, Ludovic Debure, Meng Qian, Eugene Laska, Carole Siegel, Nicholas Milton, Jennifer Newman, Esther Blessing, Meng Li, Amit Etkin, Charles R. Marmar, Silvia Fossati   +13 more
doaj   +1 more source

Ventrolateral prefrontal cortex activation and attention bias in response to angry faces in adolescents with generalized anxiety disorder [PDF]

, 2006
OBJECTIVE: While adolescent anxiety disorders represent prevalent, debilitating conditions, few studies have explored their brain physiology. Using event-related functional magnetic resonance imaging (fMRI) and a behavioral measure of attention to angry ...
Erin Mcclure, Karin Mogg, Monique Ernst, Christopher S. Monk, Ernst, Monique, Monk, Christopher, Nelson, Eric E., Charney, Dennis S., Ellen Leibenluft, Bradley, Brendan P, Monk, Christopher S., James R, Dennis S. Charney, Chen, Gang, Chen, Geng, Gang Chen, Eric E. Nelson, Nelson, Eric E, Christopher Monk, McClure, Erin, Leibenluft, Ellen, Brendan P. Bradley, Erin B. Mcclure, Blair, James R., Pine, Daniel, Daniel Pine, Bradley, Brendan P., Blair, James R, Mogg, Karin, Pine, Daniel S, McClure, Erin B., McClure, Erin B, Pine, Daniel S., Charney, Dennis S   +33 more
core   +1 more source