Results 81 to 90 of about 1,916,432 (308)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Does state-level supplemental nutrition assistance program access reduce firearm mortality among black youth? A two-way fixed effects analysis of age-stratified and cause-specific outcomes across 22 states, 2000–2020

BMC Pediatrics
Background Firearm-related injuries represent a growing public health crisis disproportionately affecting Black youth in the United States. While research has established strong associations between poverty and community violence, the potential for ...
Ebony D. Johnson, Courtney Hoge, Tasfia Jahangir, Melvin D. Livingston, Kelli Komro, Briana Woods-Jaeger   +5 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Negative Effects of Early English Education on Korean Children [PDF]

, 2018
It may be fairly said that most countries around the world are joining the English-speaking world since English became one of the popular languages. In this situation when the importance of English is emphasized, people’s reaction to and recognition of ...
Hwang, Saebyuk
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Academic help seeking behavior as a mediator of the relationship between social skill and mathematics achievement among primary school students

Scientific Reports
This study aimed to examine the mediating role of students’ academic help-seeking behavior in explaining the relationship between students’ social skills as motivational orientation and mathematics achievement among primary schools of Grade 8 students ...
Fasika Teshale Wole, Reda Darge Negasi, Amare Sahile Abebe   +2 more
doaj   +1 more source

The Efficacy of Cognitive Behavioral Group-Therapy Alone and plus Family Psycho-Education on the Treatment of Major Depression Disorder Symptoms in Females [PDF]

, 2012
: Background & Aims: Major depression is one of the common psychiatric disorders imposing negative effects on patients and their families. There are several treatment methods for depression.
Solati Dehkordi K., Mobasheri M.,
core  

Behavioral Economics and Workforce Development: A Review of the Literature from Labor Economics and the Broader Field [PDF]

, 2016
Literature Reviewhere is mutual benefit for employers and workers when workers improve their skills beyond the minimum requirements for their position—a fact not lost on employers, many of who are willing to provide education and training opportunities ...
Juniper, Cynthia J., Prince, Heath J.
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source