Results 101 to 110 of about 4,194,676 (300)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Perspectivas de la psicología de la salud en Colombia Health psychology perspectives in Colombia
Investigación y Educación en Enfermería, 2006 El propósito de este artículo es ofrecer una breve revisión histórica sobre el desarrollo de la psicología de la salud, su origen y surgimiento como campo aplicado de la psicología, puntualizando especialmente en Colombia.
Françoise Contreras T +3 more
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PLoS ONE, 2017 Drawing on the theory of social action in organizational and institutional sociology, this paper examines the behavioral consequences of plural logics of action.
Jae-Mahn Shim
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Fulfilling our assignment to improve the health of all: good science just isn't enough
, 2008 This article was the presidential address presented at the Society of Behavioral Medicine 2005 SBM Annual Meeting and Scientific Sessions, April 13 to 16, 2005, Boston, Massachusetts.
Ockene, Judith K.
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Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Journal of Pain Research, 2017 Sara Cederbom,1 Eva Denison,2 Astrid Bergland1 1Department of Physiotherapy, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway; 2Department of Physiotherapy, School of Health, Care and Social Welfare, M ...
Cederbom S, Denison E, Bergland A
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Family Medicine Physician Readiness to Treat Behavioral Health Conditions: A Mixed Methods Study
Journal of Primary Care & Community HealthIntroduction: Behavioral and mental health conditions present significant challenges in the United States where access to care is limited. Family medicine physicians play a crucial role in addressing these challenges, often serving as frontline ...
Ashlyn Chea +2 more
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Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source