Results 171 to 180 of about 263,500 (249)
RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann +26 morewiley +1 more sourceGenome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes
Advanced Science, EarlyView.This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium +51 morewiley +1 more sourceAllosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro +28 morewiley +1 more sourceManagement / Ethics / Welfare Genetics / Breeding / Gene Function Bioresource Developmental Engineering / Regenerative Therapy Infectious Diseases / Immunology / Pathology Disease Model Neuroscience / Behavior
, 2011 Yoshihiro Inoue, Takashi Ishibashi, Yohei Kudo, -Huichi -Asaki, Tomohiro Takahashi, Hitoshi Ohkubo, Yasuhisa Matsui, Azusa Hata, Tomoya Nakamachi, -Atoru Arata, Seiji Shioda, Ryuichito Ando, Syuki Ojima, Yuko Moriya, Ando, Kenji Sakuma, Keiko Otokuni, Shinichi Kamijo, Hisakage Funabashi, Hideaki Matsuoka, Kazuyuki Mekada, Makoto Iizuka, Masashi Yokota, Megumi Kobayashi, Atsushi Yoshiki, Ayako Nishio, Yasuo Nakamura, Hisashi Kuromatsu, Michiko Komai, Kiyoshi Matsumoto, Tetsu Nishikawa, Naoki Morishita, -Hin Nakamura, Mitsunaga Fusako, Yuki Yoshimura, Kazuomi Nakamura, -Higeyuki Yamaguchi, Shiho Endo, Yoshihiro Nakajima, Yasuhiro Kazuki, Yoshihiro Ohmiya, Mitsuo Oshimura, Tetsuya Ohbayashi, Noriyoshi Hashimoto, Takumi Nishiuchi, Ikuko Hara-Nishimura, Masahide Asano, Yoshitaka Fujihara, Yuhkoh Satouh, Naokazu Inoue, Ayako Isotani, Masahito Ikawa, Masaru Okabe, Mizuki Iina, Takashi Ohkubo, Wataru Ueno, Tatsuo Hayao, Kazuhiro Okumura, Yuki Miyasaka, Jian-Hua Mao, Ikuo Miura, -Higeharu Wakana, Ryo Kominami, Yuichi Wakabayashi +63 moreopenalex +2 more sourcesDelta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine
Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li +13 morewiley +1 more source
