Results 101 to 110 of about 1,971,830 (326)

Cross-talk in economics and neuroscience [PDF]

Neuroeconomics is a recent extension of behavioral economics which aims at uncovering the brain mechanisms and activities that mediate regular and anomalous behaviour. Gul and Pesendorfer (2005) have launched a critique against the neuroeconomic research
Carl Schoonover, Sacha Bourgeois-Gironde
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Combining the contributions of behavioral economics and other social sciences in understanding taxation and tax reform [PDF]

, 2015
publication-status: Publishedtypes: ArticleThis version uploaded to Munich Personal RePEc ArchivePaper presented at the Conference of the Society for the Advancement of Behavioral Economics, San Diego State University, August 2-5, 2010This paper extends ...
James, Simon
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Vers un « nouvel Adam » ?

Revue d’Histoire des Sciences Humaines, 2020
Thomas Hirsch
doaj   +1 more source

"Mental Disorders as Brain Diseases": Bioethical, Cultural, and Social Implications

Revista de Bioética y Derecho
Background: Advances in modern neuroscience have led to a transformation in the understanding of mental disorders, which are now being reinterpreted as "brain diseases." Objective: To analyze the social, cultural, and bioethical implications of the shift
Lucas Franca Garcia, Sophia Ivantes-Rodrigues, Leonardo Pestillo de Oliveira, José Roberto Goldim   +3 more
doaj   +1 more source

Discussion on the Borrowing of Behavioral Science Theory for Ideological and Political Education Methods [PDF]

, 2017
Lei Wang
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model

iScience
Summary: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by cognitive decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong link between sleep disturbances and AD progression, with disrupted sleep ...
Luyan Zhang, Letizia Santoni, Nam Anh Ngo, Reyila Simayi, Eleonora Ficiará, Luisa de Vivo, Michele Bellesi   +6 more
doaj   +1 more source