Results 91 to 100 of about 4,902,943 (336)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Gender Gaps In Voter's Behaviour In Modern Ukraine: Factors And Influence [PDF]

open access: yes, 2018
The article deals with the important and insufficiently studied problem of specificity of the gender influence on electors' orientations in modern Ukraine.
Dziuba, N. (Nataliia)
core  

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Playing the piano with a robotic third thumb: assessing constraints of human augmentation

open access: yesScientific Reports, 2021
Contemporary robotics gives us mechatronic capabilities for augmenting human bodies with extra limbs. However, how our motor control capabilities pose limits on such augmentation is an open question. We developed a Supernumerary Robotic 3rd Thumbs (SR3T)
Ali Shafti   +4 more
doaj   +1 more source

MIA HALL’S BEHAVIOUR CHANGE IN GAYLE FORMAN’S IF I STAY [PDF]

open access: yes, 2016
This final project analysis Gayle Forman’s novel entitled: If I Stay. The purpose of this final project is to analysis the behaviour change of the main character, Mia Hall.
Kusumaningrum, Kusumaningrum
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

Applications of the theory of planned behaviour to drivers' speeding behaviour [PDF]

open access: yes, 2004
The theory of planned behaviour (TPB; Ajzen, 1985, 1988, 1991) provides apotentially useful approach for investigating the links between drivers' attitudes andbehaviour and for informing road safety interventions that aim to promote 'safe' driving.
Armitage, C.J.   +2 more
core  

Interviews of deshopping behaviour: An analysis of theory of planned behaviour [PDF]

open access: yes, 2003
Research reveals alarming results on the prevalence of the dishonest consumer behaviour known as deshopping. Deshopping is the “deliberate return of goods for reasons other than actual faults in the product, in its pure form premeditated prior to and ...
Dennis, C, King, T
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Dissecting task-based fMRI activity using normative modelling: an application to the Emotional Face Matching Task

open access: yesCommunications Biology
Functional neuroimaging has contributed substantially to understanding brain function but is dominated by group analyses that index only a fraction of the variation in these data.
Hannah S. Savage   +7 more
doaj   +1 more source

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