Results 251 to 260 of about 5,896,146 (352)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The impact of COVID-19 infection experience on risk perception and preventive behaviour: a cohort study. [PDF]

Epidemiol Infect
Murakami M, Yamagata M, Miura A.
europepmc   +1 more source

Modelling and Simulating of Risk Behaviours in Virtual Environments Based on Multi-Agent and Fuzzy Logic

, 2013
Linqin Cai, Zhuo Yang, Simon X. Yang, Hongchun Qu   +3 more
openalex   +1 more source

Charging behaviour in persistent phosphors [PDF]

, 2011
Poelman, Dirk, Smet, Philippe, Van den Eeckhout, Koen   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

COVID-19 stress, aggressiveness, and deviant behaviour: a mediation analysis of youth in the pandemic era. [PDF]

Aust J Psychol
Uvelli A, Floridi M, Guarino A, Tonini B, Prati G, Casale S, Masti A, Gualtieri G, Ferretti F.   +8 more
europepmc   +1 more source

Low-light-level therapy as a treatment for minimal hepatic encephalopathy: behavioural and brain assessment

, 2016
Natalia Arias, Marta Méndez, Jorge L. Arias   +2 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Associations between food-related behaviours, nutrient intake and nutritional status through Structural Equation Model (SEM) among clients undergoing Community-Based Treatment and Rehabilitation (CBTaR): A cross-sectional study in Kelantan, Malaysia. [PDF]

BMJ Open
Aji AS, Rohana AJ, Geik OP, Rafdinal W, Wan Mohammad WMZ, Mohd Yasin MA, Tengku Ismail TA, Vanoh D, Mohamed NN.   +8 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source