Results 181 to 190 of about 359,828 (296)

Co-design of a complex school-based intervention for attention deficit/hyperactivity disorder using the Intervention Mapping approach. [PDF]

JCPP Adv
Russell A, Holt S, Wellaway I, Hirst A, Heaney L, Hanna R, Wenger J, Hampton L, Sullivan B, Townsend F, Ford T, Dunn BD, Moore D, Sonuga-Barke E, Pfiffner L, Kidger J, Hayes R, Gudka R, Bryant E, Cordwell K, Tools for Schools Planning Group.   +20 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Designing and Conducting Motivational Interviewing Research in Veterinary Clinical Settings: A Practical Guide for Researchers. [PDF]

Animals (Basel)
Gates MC, Phythian CJ, Britt E.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

How lifestyle counselling supports behaviour change among Thai adults with non-communicable diseases: a rapid realist review. [PDF]

BMJ Open
Chen B, Angkurawaranon C, Papachristou Nadal I.   +2 more
europepmc   +1 more source

Teachers’ Priorities for Change in Australian Schools to Support Staff Well-Being

, 2017
Adam Garrick, Anita S. Mak, S. Cathcart, Peter Winwood, A. Bakker, K. Lushington   +5 more
semanticscholar   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Empowering Parent Carers of Children With Neurodisability in Healthcare Settings: Co-Producing a Theory of Change for Intervention Development. [PDF]

Health Expect
Reeder J, Minhas S, Breuer E, Smith JR, Kendall S, Morris C.   +5 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Social-emotional competencies and health-related outcomes of health promotion in upper secondary education: a scoping review of German-speaking countries. [PDF]

Front Psychol
Kerzendorfer-Breithardt M.
europepmc   +1 more source