Results 101 to 110 of about 7,525,661 (238)

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Geometry‐Encoded Actuation as a Structural Interaction Layer in Origami Robots

Advanced Science, EarlyView.
We present geometry‐encoded actuation (GEA), a design framework that integrates multistable origami with liquid crystal elastomer actuators to encode environmental interactions into autonomous structural responses. GEA enables programmable shape transformation without continuous sensing or complex control, achieving robust adaptive manipulation and ...
Jianshu Zhou, Yitong Li, Junda Huang, Ian Zhang, Haoran Liu, Boyuan Liang, Yiyuan Zhang, Xiaohui Xiao, Qiguang He   +8 more
wiley   +1 more source

DESIGNING BEHAVIOR CHANGE INTERVENTIONS: THE BEHAVIOUR CHANGE WHEEL AND BEHAVIOR CHANGE TECHNIQUES

, 2014
DESIGNING BEHAVIOR CHANGE INTERVENTIONS: THE BEHAVIOUR CHANGE WHEEL AND BEHAVIOR CHANGE ...
Susan Michie (125435), Wendy Hardeman (46204), Caroline Wood (3469247), Marie Johnston (18271), Charles Abraham (13056234), Robert West (306586)   +5 more
core  

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Application of the Behaviour Change Wheel to Promote Utilisation of a Cognitive Impairment Screening Tool

Global Implementation Research and Applications
Abstract The Youth Risk of Cognitive Impairment Toolkit (Youth ROCIT) is a free, online written guide designed to help health and mental health workforces screen for risk of cognitive difficulties in young people aged 12–25. The Behaviour Change Wheel (BCW) provides a structured approach to behaviour change initiatives for workforces and can ...
Isabel Zbukvic, Shayden Bryce, Vita Pilkington, Robyn Mills, Desiree Smith, Laksha Alahakoon, Caroline Crlenjak, Melinda Benson, Jacinta Delprado, Jody Kamminga, Kelly Allott   +10 more
openaire   +1 more source

A Robotic Testing Platform for Pipelined Discovery of Resilient Dielectric Elastomer Actuators

Advanced Science, EarlyView.
This work introduces a robotic testing platform enabling high‐throughput, multi‐parameter lifetime mapping of linear dielectric elastomer actuators (DEAs). By integrating programmable high‐voltage control and automated electromechanical measurements, the system identifies material and operating conditions that double actuator lifetime.
Ang (Leo) Li, Alexander Yin, Alexander White, Sahib Sandhu, Anatol Gogoj, Denise Maria de Andrade, Matthew Francoeur, Victor Jimenez‐Santiago, Van Remenar, Codrin Tugui, Mihai Duduta   +10 more
wiley   +1 more source

3D Printed Meter‐Scale Soft Origami Robots Capable of Load‐Bearing Actuation Via Crease Stiffness Modulation

Advanced Science, EarlyView.
Origami has inspired numerous soft deployable mechanisms for safe human‐robot interaction, while its intrinsic kinematic instability at arbitrary configurations limited their practical robotic application. This work presents a 3D printed meter‐scale origami robotic actuator capable of load‐bearing deformation through creaseline stiffness modulation.
Sung Yol Yu, Sang‐Joon Ahn, Wonchul Lee, Seunguk Moon, Hyun‐Jin Hong, Kyu‐Jin Cho   +5 more
wiley   +1 more source

High‐Power Hybrid Nanogenerator With Multi‐Degree‐of‐Freedom Mechanical Coupling for Harvesting Water Wave Energy

Advanced Science, EarlyView.
A high‐power hybrid nanogenerator (HP‐HNG) with multi‐degree‐of‐freedom mechanical coupling is reported, integrating multi‐directional wave energy for output to achieve 1 + 1 > 2 energy harvesting. The HP‐HNG achieves a peak output power of 0.764 W, corresponding to a peak power density of 127.303 W m−3. At a wave frequency of 1 Hz, the HP‐HNG delivers
Shuai Ding, Hua Zhai, Hao Gong, Xiao Long, Yuanzhuo Tian, Zhanyong Hong, Long Zheng, Xucong Wang, Xiangyu Chen, Zhong Lin Wang   +9 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Dietary Behaviour Change in Adolescence. [PDF]

, 1995
PhDDiet is an important determinant of health, especially during adolescence when growth and development are critical. Many young people continue however to eat a diet that does not conform with current dietary recommendations Relatively little ...
Watt, Richard Geddie
core   +1 more source