Results 121 to 130 of about 864,495 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The role of information in a lifetime process - a model of weight maintenance by women over long time periods

Information Research: An International Electronic Journal, 2006
Introduction. This paper proposes a model of information behaviour of women during their life-long struggle to maintain normal weight. Method. The model is integrative and contextual, built on existing models in information science and several other ...
Judit Bar-Ilan, Nira Shalom, Snunith Shoham, Shifra Baruchson-Arbib, Irith Getz   +4 more
doaj  

Marginal Railway Infrastructure Costs in a Dynamic Context

European Journal of Transport and Infrastructure Research, 2008
In this paper, dynamic aspects of railway infrastructure operation and maintenance costs in Sweden are explored. Econometric cost functions are estimated to check the robustness of previous marginal cost estimates by introducing lags and leads of both ...
Mats Andersson
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Relationship between peer conformity and reproductive health maintenance behaviours among early adolescent girls in Islamic boarding schools

Healthcare in Low-resource Settings
Reproductive health problems are often experienced by early adolescents who live in Islamic boarding schools because Islamic boarding schools have a higher population density and interpersonal contact than other schools.
Peni Perdani Juliningrum, Lantin Sulistyorini, Layinatul Qoriah, Ira Rahmawati, Nuning Dwi Merina   +4 more
doaj   +1 more source

Understanding Māori youth smoking : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]

, 2007
The understanding of Māori youth smoking from a qualitative perspective has been neglected in the literature. While there has been a wide scope of research detailing the promoting and protective factors that put Māori youth at risk to smoking, there ...
Nepe, Melanie
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Experimental characterization of the structural response of adobe arches [PDF]

, 2012
Earth was one of the first construction materials used by mankind and has been used as a building material since ancient times until the present days. Its qualities related to thermal comfort, low cost or simple construction techniques have contributed ...
Costa, A., Oliveira, C., Sousa, O., Varum, H., Vicente, N.   +4 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Learner wellbeing and behaviour [PDF]

The Learner wellbeing and behaviour policy pertains to learners, teachers, parents, schools and relevant staff and is concerned with the creation and maintenance of safe and inclusive learning environments in order to provide learners with the best ...

core