Results 221 to 230 of about 864,495 (308)

Rationale and design of a parallel randomised trial of a plant-based intensive lifestyle intervention for diabetes remission: The REmission of diabetes using a PlAnt-based weight loss InteRvention (REPAIR) trial. [PDF]

Diabetes Obes Metab
McKay B, El Chaar D, Paquette M, Vallis M, Sherifali D, Oh P, Marzolini S, Dasgupta K, Booth G, Lean M, Gerstein HC, Salas-Salvadó J, Beaudry JL, Marinangeli CPF, de Souza RJ, Leiter LA, Kendall CWC, Jenkins DJA, Sievenpiper JL, Chiavaroli L.   +19 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Compliance with the recommended daily intake of at least 400g of fruits and vegetables and its relationship with behavioural change stages in Mexican adults. [PDF]

J Nutr Sci
Jiménez-Aguilar A, Uribe-Carvajal R, Salazar-Coronel A, Álvarez-Sánchez C, Rodríguez-Ramírez S, Ramírez-Silva I, Shamah-Levy T, Morales-Ruán C.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Move to Improve: Co-Designing a Hospital-Based Physical Activity Program for Children With Chronic Health Conditions. [PDF]

Health Expect
Sivaramakrishnan H, Jones AF, Long T, Naylor L, Valentine J, Martin L, Haustead L, Shetty V, Wood F, Davis E, Move to Improve Author Group.   +10 more
europepmc   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

Is it Time to Better Harness Artificial Intelligence for Improving Lifestyle Behaviours? [PDF]

Int J Public Health
Chaput JP, Lopes MVV, LeBlanc AG, Goldfield GS.   +3 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain. [PDF]

Eur J Pain
Blechschmidt V, Schlickenrieder B, Husk JR, Hoheisel U, Mörz H, Treede RD, Greffrath W.   +6 more
europepmc   +1 more source