Results 231 to 240 of about 4,013,179 (303)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

GBR 12909, a Selective Dopamine Transporter Inhibitor, Differentially Modulates Affective, Exploratory and Cognitive Domains in Zebrafish. [PDF]

Eur J Neurosci
Pretzel CW, Moraes HS, Müller ML, Fontoura K, Menezes RS, Canzian J, Barreto RE, Resmim CM, Fontana BD, Rosemberg DB.   +9 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Pain and its association with device-measured activity patterns in older adults: age and sex differences in a population-based cross-sectional study. [PDF]

Eur Rev Aging Phys Act
Lager C, Dove A, Rizzuto D, Ars J, Boström AM, Calderón Larrañaga A, Welmer AK.   +6 more
europepmc   +1 more source

Psychometric Evaluation of the Turkish Mind Excessively Wandering Scale in Adolescents With ADHD: Exploratory Findings on Age-Related Differences in Excessive Mind Wandering. [PDF]

Int J Dev Neurosci
Güler HA, Bozkur B, Akbulut ÜH, Tezcan ME, Kandeğer A.   +4 more
europepmc   +1 more source

Mandibular Hemangiomatous Ameloblastoma: A Case Report and Literature Review. [PDF]

Case Rep Dent
Shanmuha Priya S, Kolari V, Adyanthaya S, Moidin S, Raina KM.   +4 more
europepmc   +1 more source

Genetic and behavioural architecture of childhood eating behaviour and links to obesity risk

Karimi R, Baur M, Power G, Sundfjord J, Fragoso-Bargas N, Clement L, Andreassen O, Davey Smith G, Njølstad P, Brandlistuen R, Ask H, Hemani G, Ong K, Kutalik Z, Havdahl A, Vaudel M, Johansson S.   +16 more
europepmc   +1 more source

Marital conflict resolution through schema therapy and mutual behaviour analysis for enhanced self-differentiation in Kwara State. [PDF]

Front Sociol
Adegboyega LO, Odebode AA, Ajiboye SK, Awoyemi AO, Odutayo SO, Balogun AO.   +5 more
europepmc   +1 more source