Results 111 to 120 of about 6,486,296 (378)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Coping, stress and suicide ideation in the South African Police Service in the Eastern Cape

open access: yesSouth African Journal of Economic and Management Sciences, 2003
The objective of this research is to determine the relationship between coping and stress on the one hand and suicide ideation among police members on the other. A cross-sectional survey design was used.
R Meyer, S Rothmann, J Pienaar
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Fear in horses [PDF]

open access: yes, 2006
Fear is generally considered to be an undesirable emotional state that may reduce welfare, growth and reproductive performance in animals. Fear in horses is additionally problematic, because fear reactions can cause serious injury to both horse and human.
Christensen, Janne Winther
core  

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

MECHANISMS OF GOVERNANCE OF SUSTAINBLE DEVELOPMENT [PDF]

open access: yes
In this paper we incorporate the interdisciplinary New Institutional and Transaction Costs Economics (combining Economics, Organization, Law, Sociology, Behavioural and Political Sciences), and suggest a framework for analyzing the mechanisms of ...
Hrabrin Bachev
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Strengths and limits of behaviour change to foster the green transition

open access: yesField Actions Science Reports, 2022
Behavioural approaches increasingly tend to be seen as one of the “go-to” approaches when it comes to solving environmental issues: to address energy and water consumptions, improve agriculture practices, preserve biodiversity, reduce GHG’s emissions ...
Liam Smith
doaj  

International Encyclopedia of the Social and Behavioural Sciences: 3 Papers [PDF]

open access: yes
R&D, economics of science, science funding ...
Ben Martin   +3 more
core  

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