Results 41 to 50 of about 172,701 (305)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

ETHOLOGY AND WHAT NEXT? SOME PHILOSOPHICAL QUESTIONS INFLUENCING THE RESEARCH ON ANIMAL BEHAVIOUR [PDF]

Filozofia i Nauka, 2019
Animal behaviour and its underlying causal factors are investigated by numerous behavioural sciences. Ethology, one of the most important classical behavioural sciences, is concerned with the description and quantification of behaviour and the analysis ...
Ewa Joanna Godzińska
doaj  

O ensino das ciências sociais nas escolas profissionais na área da saúde no Brasil The teaching of social sciences in the Brazilian professional schools in the health field

Revista de Saúde Pública, 1976
Foi realizado em fins de 1971 um levantamento sobre o ensino das ciências sociais ou do comportamento nas escolas profissionais brasileiras na área da saúde. Das 162 escolas existentes, 122 responderam ao questionário. Destas, 85 informaram incluir temas
Reginaldo Zaccara de Campos, Everardo Duarte Nunes   +1 more
doaj   +1 more source

Women shaping behavioural science

Nature Human Behaviour
In the month of International Women’s Day, we asked six scientists about the most influential woman who shaped their field. They highlight well-known names and rising stars. Some of them have studied gender equality, and all have made tremendous efforts towards achieving it.
Cai, Qing, Hicks, Mar, Huerta-Sanchez, Emilia, Klar, Samara, Natsuaki, Misaki N, van der Lippe, Tanja   +5 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Development of a framework for assessing train passengers' post‐boarding behaviours based on their perceptions

IET Intelligent Transport Systems
While existing literature has focused on modelling pedestrian movement on platforms, there is a lack of understanding of passengers' perceptions, motivations, and influential factors that shape their on‐board behaviours and choices.
Jie Yang, Nirajan Shiwakoti, Richard Tay
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Does the opinion of the therapeutic team match with psychometric measures during the course of eating disorders?

Nutrición Hospitalaria, 2013
Introduction: Is there a group of psychometric variables, which correlates with the criteria of an interdisciplinary team about the course of ED?
I. Jáuregui-Lobera, O. Garrido-Casals, M. J. Santiago, P. Bolaños-Ríos, I. Ruiz-Prieto   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source