Results 41 to 50 of about 1,144,913 (219)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Efficacy and Safety of Infliximab in Intestinal Behçet’s Disease: A Multicenter, Phase 3 Study (BEGIN)

Gut and Liver, 2023
Background/Aims: To date, there is no prospective study that specifically investigated the efficacy of infliximab in intestinal Behçet’s disease (BD). This study evaluated the efficacy of infliximab in patients with moderate-to-severe active intestinal ...
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim, BEGIN Study Group   +12 more
doaj   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

BİLATERAL PLEVRA VE PERİKARD SIVISI OLAN BİR BEHÇET HASTALIĞI OLGUSU

Cerrahpaşa Medical Journal, 2014
Background and Observation.­ Behçet's syndrome is a primary vasculitis. In addition to mucocutaneous; ophthalmic and musculoskeletal symptoms, rarely pleural and pericardial fluid is reported in Behçet's patients due to thrombosis of superior ...
Mehmet SOY, Süleyman ÖZBEK, Abdullah CANATAROĞLU, Eren ERKEN   +3 more
doaj  

Serum amylin level in Behçet’s disease and relation to parameters of metabolic syndrome and disease activity

Egyptian Rheumatology and Rehabilitation, 2018
Background Insulin resistance is found in Behçet’s disease and associated with the development of metabolic syndrome. Our study explored whether amylin, which is involved in insulin resistance and development of metabolic syndrome, is observed in ...
Shimaa M Abdelwhab, Omima Z Shehata, Yousry A El Magd, Amal Kamal   +3 more
doaj   +1 more source

Patient Presenting with Hemoptysis: A Case of Hughes-Stovin Syndrome

Türk Osteoporoz Dergisi, 2023
Hughes-Stovin syndrome (HSS) is a very rare autoimmune clinical disorder that has been described as the presence of thrombophlebitis and multiple aneurysms in pulmonary and/or bronchial arteries.
Kezban Armağan Alptürker, Özgür Akgül   +1 more
doaj   +1 more source

Exome Sequencing Uncovers Phenotypic and Genotypic Heterogeneity in 196 Indian Families Evaluated for Autoinflammatory Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger, Periyasamy Radhakrishnan, Suma Balan, Anand P. Rao, Prajna Udupa, Karthik Vijay Nair, Bhagesh Hunakunti, Adarsh Pooradan Prasannakumar, Sanket Limaye, Huzail Gani Shaikh, Rohit Naik, Mahesh Janarthanan, Sudharshan Sridharan, Vishal Sondhi, Sheela Nampoothiri, Hitesh Shah, Sabrinath Mahadevan, Mahabaleshwar Mamadapur, Devang Pandya, Katta Mohan Girisha, Abhay Shivpuri, Amita Moirangthem, Jyothi Raghuram, Gandham Sri Lakshmi Bhavani, Sachin Jeevanagi, Girish Subramaniam, Amita Aggarwal, Anju Shukla, Dhanya Lakshmi Narayanan   +28 more
wiley   +1 more source

Seven-Year Follow-up of Neurologic Involvement in Behcet Syndrome

, 1996
Objective: To determine the long-term prognosis of neurologic involvement in Behcet syndrome. Design: Forty-six patients with Behcet syndrome, who had been the subjects of a previous report with short-term follow-up, were reexamined 7 years later; 42 of ...
P. Serdaroglu, Yurdakul, Sebahattin, Bahar, S, E. Aktin, S. Yurdakul, AkmanDemir, G, Serdaroglu, P, Aktin, E, Yazici, H, Gurvit, H, BaykanKurt, BETÜL, B. Baykan-Kurt, H. Gurvit, H. Yazici, G. Akman-Demir, S. Bahar   +15 more
core   +1 more source

Infliximab in the treatment of Budd-Chiari syndrome in Behçet’s disease

Reumatismo, 2019
Behçet’s disease is a chronic autoinflammatory disorder that usually presents with recurrent oral and genital ulcers, uveitis, skin lesions and arthritis.
L.B. Santos, J. Rigueira, A.P. Vilas
doaj   +1 more source