Results 221 to 230 of about 172,738 (259)

The Physiological Significance of Brown Adipose Tissue and the Beiging of White Adipose Tissue in People

2017
The recent discovery of functional brown adipose tissue (BAT) in adults has stimulated intense interest for its therapeutic potential against obesity and its related metabolic conditions. Although rodent studies support the importance of brown and beige adipocytes in metabolic health, a smaller number of clinical investigations have examined their ...
Maria Chondronikola, Labros S. Sidossis
openaire   +1 more source

Inducible brown/beige adipocytes in retro-orbital adipose tissues

Experimental Eye Research, 2019
Beige adipocytes and brown adipocytes can generate heat by using mitochondrial uncoupling protein 1 (Ucp1), a thermogenic protein. Browning/beiging is the emergence of beige adipocytes in white adipose tissues (WAT) for cold acclimatization. Here we show the existence of brown/beige adipocytes in retro-orbital WAT in mice. Histologically, Ucp1-positive
Makoto, Sugiyama, Daichi, Shindo, Norihisa, Kanada, Takahiro, Ohzeki, Kazuki, Yoshioka, Masayuki, Funaba, Osamu, Hashimoto   +6 more
openaire   +2 more sources

ADIPOGENESIS FEATURES OF WHITE, BEIGE AND BROWN ADIPOSE TISSUES

BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2021
White and brown adipose tissue is present in the human body and is well described. As well as the effect of the type of fat on human health, in particular obesity, type 2 diabetes, insulin tolerance. The presence and distribution of different types of fat in pigs has not been adequately described.
openaire   +1 more source

Transplantation of beige adipose organoids fabricated using adipose acellular matrix hydrogel improves metabolic dysfunction in high‐fat diet‐induced obesity and type 2 diabetes mice

Journal of Cellular Physiology
Transplantation of brown adipose tissue (BAT) is a promising approach for treating obesity and metabolic disorders. However, obtaining sufficient amounts of functional BAT or brown adipocytes for transplantation remains a major challenge.
Yuping Quan, Jian Li, Junrong Cai, Yunjun Liao, Yuteng Zhang, Feng Lu   +5 more
semanticscholar   +1 more source

Impact of Estrogens on the Regulation of White, Beige, and Brown Adipose Tissue Depots

Comprehensive Physiology, 2019
ABSTRACTAs adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity‐associated diseases. Adipose tissues are broadly characterized as consisting of white, beige, and brown depot types.
Gabriel B, Bernasochi, James R, Bell, Evan R, Simpson, Lea M D, Delbridge, Wah Chin, Boon   +4 more
openaire   +2 more sources

Role of developmental transcription factors in white, brown and beige adipose tissues

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
In this review we discuss the role of developmental transcription factors in adipose tissue biology with a focus on how these developmental genes may contribute to regional variation in adipose tissue distribution and function. Regional, depot-specific, differences in lipid handling and signalling (lipolysis, lipid storage and adipokine/lipokine ...
Catriona, Hilton, Fredrik, Karpe, Katherine E, Pinnick   +2 more
openaire   +2 more sources

Two-stage evolution of mammalian adipose tissue thermogenesis

Science
Brown adipose tissue (BAT) is a heater organ that expresses thermogenic uncoupling protein 1 (UCP1) to maintain high body temperatures during cold stress.
S. Keipert, Michael J. Gaudry, Maria Kutschke, Michaela Keuper, Margeoux A. S. Dela Rosa, Yiming Cheng, J. M. Monroy Kuhn, Rutger Laterveer, Camila A. Cotrim, Peter Giere, Fabiana Perocchi, R. Feederle, Paul G. Crichton, D. Lutter, Martin Jastroch   +14 more
semanticscholar   +1 more source

Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition

Cells
Adipose tissue (AT), once considered a mere fat storage organ, is now recognized as a dynamic and complex entity crucial for regulating human physiology, including metabolic processes, energy balance, and immune responses.
Marta López-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde, J. Arbonés-Mainar   +4 more
semanticscholar   +1 more source

Skeletal muscle-secreted myokine interleukin-6 induces white adipose tissue conversion into beige adipose tissue in myostatin gene knockout pigs.

Domestic Animal Endocrinology, 2021
Meifu Xuan, Zhao-Bo Luo, Sheng-Zhong Han, Zhouyan Li, Kai Gao, Xin-Yue Liu, Shuangyan Chang, Zheng-Yun Jin, H. Choe, Hyo-Jin Paek, Biaohu Quan, Xi-Jun Yin, Jindan Kang   +12 more
semanticscholar   +1 more source

Parkin-mediated mitophagy in beige adipose tissue

Metabolism, 2020
Zihang, Wang, Xiaofang, Zhang, Xiaodan, Lu   +2 more
openaire   +2 more sources