Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs
Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna +9 more
wiley +1 more source
Wild bee diversity in the Entre-Sambre-et-Meuse National Park (Belgium). [PDF]
Gérard M +6 more
europepmc +1 more source
Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA
A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen +8 more
wiley +1 more source
Health-related quality of life trajectories one year after COVID-19-induced ARDS: A secondary analysis of the CONFIDENT trial. [PDF]
Rousseau AF +22 more
europepmc +1 more source
Unmet needs in patients with RA judged in remission by the rheumatologist: a semi-structured interview study. [PDF]
De Meyst E +8 more
europepmc +1 more source
Desmoid Tumor of the Abdominal Wall. [PDF]
Van Herck M +2 more
europepmc +1 more source
First report of gastric muscle-retracting sign identification and endoscopic intermuscular dissection. [PDF]
Sorge A +6 more
europepmc +1 more source
The role of vaccination, underlying health conditions, and working in healthcare in the socioeconomic disparities in COVID-19 hospitalization: a mediation analysis using interventional effect models. [PDF]
Cavillot L +8 more
europepmc +1 more source

