Results 231 to 240 of about 1,651,452 (304)

Geomorphic processes on coal tips in Belgium [PDF]

, 2011
Diependaele, Stijn, Nyssen, Jan, Palmers, Jo, Poesen, Jean, Vanmaercke, Matthias, Vermeersch, Dominiek   +5 more
core  

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Real-world comparative effectiveness of SARS-CoV-2 primary vaccination campaigns against SARS-CoV-2 infections: a federated observational study emulating a target trial in three nations. [PDF]

Eur J Public Health
Meurisse M, Estupiñán-Romero F, Perola M, Paajanen T, González-Galindo J, Van Goethem N, Bernal-Delgado E.   +6 more
europepmc   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Homogenization of Northern Belgian landscapes through centuries of reclamation, agricultural transition, and urbanization. [PDF]

Nat Commun
De Keersmaeker L, Roggemans P, Poelmans L, Priem F, Taillir S, Petermans T, Van Valckenborgh J.   +6 more
europepmc   +1 more source

Effect of carbamazepine on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader, in healthy adults

British Journal of Clinical Pharmacology, EarlyView.
Aim To evaluate the effects of carbamazepine, a strong cytochrome P450 (CYP)3A4 inducer, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera estrogen receptor degrader. Methods This was a phase 1, open‐label, fixed‐sequence, two‐period study in healthy adult participants.
Hechuan Wang, Jennifer A. Winton, Kyle T. Matschke, Alexandre Stouffs, Kimberly C. Lee, Yuanyuan Zhang, Wenlian Qiao, Weiwei Tan   +7 more
wiley   +1 more source

Delayed Retrograde Reperfusion of the Aneurysmal Sac after Open Repair of an Inflammatory Abdominal Aortic Aneurysm Treated with Catheter-Directed Embolization. [PDF]

Vasc Specialist Int
Maleux G, Fourneau I, Peluso JP, Mufty H.   +3 more
europepmc   +1 more source

Country Report Belgium [PDF]

, 2008
van Puyenbroeck, Laurens, Vermeulen, Gert   +1 more
core  

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Mediterranean dietary pattern analysis combining two nutritional assessment tools in children aged 3 to 6 years in five European countries. [PDF]

Eur J Nutr
Triebswetter A, Erhardt J, Totzauer M, Luque V, Gispert-Llaurado M, Verduci E, Gruszfeld D, Xhonneux A, Koletzko B, Grote V.   +9 more
europepmc   +1 more source