Results 121 to 130 of about 3,586,308 (370)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

KUR'AN IŞIGINDA DÜŞÜNCE, iNANÇ VE iFADE HÜRRiYETi

open access: yesFırat Üniversitesi İlahiyat Fakültesi Dergisi, 2005
According to the Qur'an no one has the right to oppress or interfere wıtlı anya ne 's fa ith or beliejs. Human beings are completely free to believe or not to believe anything they choose wlıetlıer they practice or not wlıat they believe in.
Abdulbaki Güneş
doaj  

Beyond Belief: Chance, Authorship, and the Limits of Comprehension in Gerhard Richter’s Strip

open access: yesReligions, 2019
For nearly six decades, Gerhard Richter has challenged the conceptual and visual limits of contemporary painting. His 2011 work Strip overloads the viewer’s visual perception.
James Romaine
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Non‐Scientific Criteria for Belief Sustain Counter‐Scientific Beliefs [PDF]

open access: bronze, 2018
S. Emlen Metz   +2 more
openalex   +1 more source

Hertz beyond belief

open access: yesSoft Matter, 2014
We examine the validity of Hertz's linear elastic theory for central collisions using a viscoelastic model. This model explains why Hertz's theory is accurate in predicting the collision time and maximum contact area even when $40\%$ of the kinetic energy is lost due to viscous dissipation.
He, Andong, Wettlaufer, John S.
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

UYGUR TÜRKLERİNİN İNANÇ VE UYGULAMALARINDA TOPRAK

open access: yesUluslararası Uygur Araştırmaları Dergisi, 2018
Uygurlar kendinden önce hâkim olmuş Hun ve Köktürklerin kültür mirası üzerine kurulmuş olmakla beraber, bu devletlere nazaran tam bir yerleşik hayata geçmesi ve artık taş üzerine yazılmış belgeler yerine kâğıtlar üzerine yazılmış belgeler bırakmaları ...
Kübra Yıldız Altın
doaj  

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