Results 141 to 150 of about 5,670,665 (286)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Credition and the neurobiology of belief: the brain function in believing
Academia BiologyCredition, derived from the Latin credere (to believe), has been advocated recently as a central brain function accommodating the multifaceted processes of believing.
Hans-Ferdinand Angel, Rüdiger J. Seitz
doaj +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Belief functions on real numbers
International Journal of Approximate Reasoning, 2005 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +4 more sources
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Reality and Paternity in the Cinema of the Dardennes
Journal for Religion, Film and Media, 2016 The Dardenne brothers’ filmic production aims at restoring the missing link between human beings and the world that has been progressively undermined during the ultimate development of late-capitalist society.
Isabella Guanzini
doaj
Cognitive Reflection and Religious Belief: A Test of Two Models
Judgment and Decision MakingExisting research suggests a negative correlation between reflective thinking and religious belief. The dual process model (DPM) posits that reflection diminishes religious belief by limiting intuitive decisions.
Fırat Şeker +6 more
doaj +1 more source
Consistent transformations of belief functions
CoRR, 2014 Consistent belief functions represent collections of coherent or non-contradictory pieces of evidence, but most of all they are the counterparts of consistent knowledge bases in belief calculus. The use of consistent transformations cs[.] in a reasoning process to guarantee coherence can therefore be desirable, and generalizes similar techniques in ...
openaire +2 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source