Results 171 to 180 of about 30,392 (251)

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

open access: yesAdvanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang   +22 more
wiley   +1 more source

Belief Revision, Uniqueness, and the Equal Weight View

open access: yesThe Reasoner, 2013
Michele Palmira
doaj  

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

open access: yesAdvanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger   +8 more
wiley   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

open access: yesAdvanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal   +25 more
wiley   +1 more source

Delicate Management of Alkaline‐Substrate‐Induced Interfacial Reactions Enables High‐Efficiency and Stable Deep‐Red CsPbI3 Perovskite Light‐Emitting Diodes

open access: yesAdvanced Science, EarlyView.
We develop a magnesium‐doping strategy to delicately modulate the alkaline substrate‐induced reactions, ensuring high‐quality CsPbI3 perovskite emissive layers with substantially improved stability. The resultant deep‐red LEDs demonstrate a high peak external quantum efficiency of 23.62% and an exceptional half‐lifetime stability of 376 h at 20 mA cm−2,
Zhennan Tian   +11 more
wiley   +1 more source

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