Results 51 to 60 of about 951,315 (252)

Irrational beliefs in posttraumatic stress responses: A Rational Emotive Behaviour Therapy approach [PDF]

, 2015
The current study aimed to test a key theoretical prediction of Rational Emotive Behaviour Therapy theory by assessing the role of general and trauma-specific irrational beliefs in the prediction of posttraumatic stress responses.
Shevlin, Mark, Adamson, Gary, Hyland, Philip, Boduszek, Daniel   +3 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Survey of early predictive signs of poor mental health and socio-cultural beliefs about mental illness in Enugu state, Nigeria

Nigerian Journal of Medicine, 2018
BACKGROUND: The rising prevalence of mental disorder and the enormous emotional, financial, socio-economic and developmental burden is a source of concern and challenge to the global community. This study assessed the prevalence of major warning signs of
O C Ekwueme, F Chukwueneke, A C Ekwueme, A C Ndu, C A Idoko, E A Nwobi   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Knowledge, belief, and perception among youths with acne vulgaris

Indian Journal of Dermatology, 2019
Background: Acne vulgaris is one of the commonest dermatological challenges faced by the youth. It lasts several years, running a chronic course with complications such as scarring.
Afzaa Nizar Machiwala, Ganesh Kamath, Tanvi Pradeep Vaidya   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A Religious Patient and Her Sleep Problems: Reflections on an Experience in which Sleeping Pills were not Prescribed

International Journal of Medical Students, 2017
The spirituality, cultural beliefs and religion of any patient are likely to have an impact on his/her health, and well-being. Health professionals, mainly young physicians and medical students, often fail to consider this type of background when taking ...
Thiago Henrique Roza
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

To assess the preparedness of primary care physicians in terms of their knowledge, attitude, beliefs, and confidence regarding smoking cessation in Gilgit

Journal of Family Medicine and Primary Care
Background Tobacco smoking poses a great threat to the healthcare system both in developed and developing countries due to its health hazard. Healthcare professionals and in particular physicians can play an effective role in encouraging people to quit ...
Bano Khadija, Tariq Swaleha
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source