Results 101 to 110 of about 56,257 (250)
Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men
Advanced Science, EarlyView.In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey +14 morewiley +1 more sourcePotent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins
Advanced Science, EarlyView.Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang +16 morewiley +1 more sourceAmmonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
Advanced Science, EarlyView.Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen +5 morewiley +1 more sourceHierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics
Advanced Science, EarlyView.We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...Samuel Tsai, Liuyang Cheng, Ali Albazroun, Qiong Wang, Jeongmin Kim, Arman Tekinalp, Soonwook Kim, Charlie Simcox, Ryne Downing, Vagish Sivaramakrishnan, Grace Carsello, Miles Bimrose, Wonsik Eom, William P. King, Mattia Gazzola, Sameh Tawfick +15 morewiley +1 more sourceStudy of Free‐Space Optical Quantum Network: Review and Prospectives
Advanced Science, EarlyView.Free from the constraints of fiber connections, free‐space quantum network enables longer and more flexible quantum network connections. This review summarizes and comparatively analyzes free‐space quantum network experiments based on ground stations, satellites, and mobile platforms.Hua‐Ying Liu, Zhenda Xie, Shining Zhuwiley +1 more sourceStudying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems
Advanced Science, EarlyView.A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin +9 morewiley +1 more sourceALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol +25 morewiley +1 more sourceMG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis
Advanced Science, EarlyView.Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu +14 morewiley +1 more sourceTest of lepton flavor universality with measurements of $R(D^{+})$ and $R(D^{*+})$ using semileptonic $B$ tagging at the Belle II experiment
Published by American Physical Society, Ridge ...Adachi, I., Adamczyk, K., Aggarwal, L., Ahmed, H., Aihara, H., Akopov, N., Alghamdi, S., Alhakami, M., Aloisio, A., Althubiti, N., Amos, K., Angelsmark, M., Ky, N. Anh, Antonioli, C., Asner, D. M., Atmacan, H., Aushev, T., Aushev, V., Aversano, M., Ayad, R., Babu, V., Bae, H., Baghel, N. K., Bahinipati, S., Bambade, P., Banerjee, Sw., Bansal, S., Barrett, M., Bartl, M., Baudot, J., Beaubien, A., Becherer, F., Becker, J., Bennett, J. V., Bernlochner, F. U., Bertacchi, V., Bertemes, M., Bertholet, E., Bessner, M., Bettarini, S., Bhardwaj, V., Bhuyan, B., Bianchi, F., Bilka, T., Biswas, D., Bobrov, A., Bodrov, D., Bolz, A., Bondar, A., Borah, J., Boschetti, A., Bozek, A., Bračko, M., Branchini, P., Briere, R. A., Browder, T. E., Budano, A., Bussino, S., Campagna, Q., Campajola, M., Cao, L., Casarosa, G., Cecchi, C., Cerasoli, J., Chang, M. -C., Chang, P., Cheaib, R., Cheema, P., Cheon, B. G., Chilikin, K., Chin, J., Chirapatpimol, K., Cho, H. -E., Cho, K., Cho, S. -J., Choi, S. -K., Choudhury, S., Cochran, J., Consigny, I., Corona, L., Cui, J. X., De La Cruz-Burelo, E., de la Motte, S. A., De Nardo, G., de Pietro, G., de Sangro, R., Destefanis, M., Dey, S., Dhamija, R., Di Capua, F., Dingfelder, J., Doležal, Z., Jiménez, I. Domínguez, Dong, T. V., Dorigo, M., Dossett, D., Dubey, S., Dugic, K., Dujany, G., Ecker, P., Epifanov, D., Feichtinger, P., Ferber, T., Fillinger, T., Finck, C., Finocchiaro, G., Fodor, A., Forti, F., Fulsom, B. G., Gabrielli, A., Gale, A., Ganiev, E., Garcia-Hernandez, M., Garg, R., Gaudino, G., Gaur, V., Gautam, V., Gaz, A., Gellrich, A., Ghevondyan, G., Ghosh, D., Ghumaryan, H., Giakoustidis, G., Giordano, R., Giri, A., Gironell, P. Gironella, Glazov, A., Gobbo, B., Godang, R., Gogota, O., Goldenzweig, P., Gradl, W., Granderath, S., Graziani, E., Greenwald, D., Gruberová, Z., Guan, Y., Gudkova, K., Haide, I., Han, Y., Hara, K., Hara, T., Harris, C., Hayasaka, K., Hayashii, H., Hazra, S., Hearty, C., Hedges, M. T., de la Cruz, I. Heredia, Villanueva, M. Hernández, Higuchi, T., Hoek, M., Hohmann, M., Hoppe, R., Horak, P., Hsu, C. -L., Huang, A., Humair, T., Iijima, T., Inami, K., Inguglia, G., Ipsita, N., Ishikawa, A., Itoh, R., Iwasaki, M., Jackson, P., Jacobi, D., Jacobs, W. W., Jaffe, D. E., Jang, E. -J., Ji, Q. P., Jia, S., Jin, Y., Johnson, A., Joo, K. K., Junkerkalefeld, H., Kaliyar, A. B., Kandra, J., Kang, K. H., Kang, S., Karyan, G., Kawasaki, T., Keil, F., Ketter, C., Khan, M., Kiesling, C., Kim, C. -H., Kim, D. Y., Kim, J. -Y., Kim, K. -H., Kim, Y. -K., Kindo, H., Kinoshita, K., Kodyš, P., Koga, T., Kohani, S., Kojima, K., Korobov, A., Korpar, S., Kowalewski, R., Križan, P., Krokovny, P., Kuhr, T., Kulii, Y., Kumar, D., Kumar, J., Kumara, K., Kunigo, T., Kuzmin, A., Kwon, Y. -J., Lacaprara, S., Lai, Y. -T., Lalwani, K., Lam, T., Lange, J. S., Lau, T. S., Laurenza, M., Leboucher, R., Lee, M. J., Lemettais, C., Leo, P., Lewis, P. M., Li, C., Li, H. -J., Li, L. K., Li, Q. M., Li, W. Z., Li, Y. B., Liao, Y. P., Libby, J., Lin, J., Lin, S., Liu, M. H., Liu, Q. Y., Liu, Y., Liu, Z. Q., Liventsev, D., Longo, S., Lueck, T., Lyu, C., Ma, Y., Madaan, C., Maggiora, M., Maharana, S. P., Maiti, R., Mancinelli, G., Manfredi, R., Manoni, E., Manthei, A. C., Mantovano, M., Marcantonio, D., Marcello, S., Marinas, C., Martellini, C., Martens, A., Martini, A., Martinov, T., Massaccesi, L., Masuda, M., Matvienko, D., Maurya, S. K., Maushart, M., Mckenna, J. A., Mehta, R., Meier, F., Meleshko, D., Merola, M., Metzner, F., Miller, C., Mirra, M., Mitra, S., Miyabayashi, K., Miyake, H., Mizuk, R., Mohanty, G. B., Mondal, S., Moneta, S., Moser, H. -G., Nakamura, I., Nakamura, K. R., Nakao, M., Nakazawa, Y., Naruki, M., Natkaniec, Z., Natochii, A., Nayak, M., Nazaryan, G., Neu, M., Nishida, S., Novosel, A., Ogawa, S., Okubo, R., Ono, H., Onuki, Y., Otani, F., Pakhlova, G., Paoloni, E., Pardi, S., Parham, K., Park, H., Park, J., Park, K., Park, S. -H., Paschen, B., Passeri, A., Patra, S., Pedlar, T. K., Peruzzi, I., Peschke, R., Pestotnik, R., Piccolo, M., Piilonen, L. E., Podobnik, T., Pokharel, S., Prakash, A., Praz, C., Prell, S., Prencipe, E., Prim, M. T., Privalov, S., Prudiiev, I., Purwar, H., Rados, P., Raeuber, G., Raiz, S., Raj, V., Rauls, N., Ravindran, K., Rehman, J. U., Reif, M., Reiter, S., Remnev, M., Reuter, L., Ripp-Baudot, I., Rizzo, G., Robertson, S. H., Roehrken, M., Roney, J. M., Rostomyan, A., Rout, N., Salutari, L., Sanders, D. A., Sandilya, S., Santelj, L., Santos, C., Savinov, V., Scavino, B., Schmitt, C., Schmitz, J., Schneider, S., Schwanda, C., Schwartz, A. J., Seino, Y., Selce, A., Senyo, K., Serrano, J., Sevior, M. E., Sfienti, C., Shan, W., Sharma, C., Sharma, G., Shi, X. D., Shillington, T., Shimasaki, T., Shiu, J. -G., Shtol, D., Sibidanov, A., Simon, F., Singh, J. B., Skorupa, J., Sobie, R. J., Sobotzik, M., Soffer, A., Sokolov, A., Solovieva, E., Song, W., Spataro, S., Spruck, B., Starič, M., Stavroulakis, P., Stefkova, S., Stroili, R., Strube, J., Sue, Y., Sumihama, M., Sumisawa, K., Sutcliffe, W., Suwonjandee, N., Svidras, H., Takahashi, M., Takizawa, M., Tamponi, U., Tanida, K., Tenchini, F., Thaller, A., Tittel, O., Tiwary, R., Torassa, E., Trabelsi, Karim, Tsaklidis, I., Uchida, M., Ueda, I., Uglov, T., Unger, K., Unno, Y., Uno, K., Uno, S., Urquijo, P., Ushiroda, Y., Vahsen, S. E., van Tonder, R., Varvell, K. E., Veronesi, M., Vinokurova, A., Vismaya, V. S., Vitale, L., Vobbilisetti, V., Volpe, R., Vossen, A., Wakai, M., Wallner, S., Wang, M. -Z., Wang, X. L., Wang, Z., Warburton, A., Watanabe, M., Watanuki, S., Wessel, C., Won, E., Xu, X. P., Yabsley, B. D., Yamada, S., Yan, W., Yan, W. C., Yelton, J., Yin, J. H., Yoshihara, K., Yuan, C. Z., Yuan, J., Zani, L., Zeng, F., Zeyrek, M., Zhang, B., Zhou, J. S., Zhou, Q. D., Zhu, L., Zhukova, V. I., Žlebčík, R., Anh Ky, N., Domínguez Jiménez, I., Gironella Gironell, P., Heredia de la Cruz, I., Hernández Villanueva, M., Le Diberder, F. R., Moreira de Carvalho, A. L., Podesta-Lerma, P. L. M., Ricalde Herrmann, D. +456 moreopenaire +7 more sources
